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Viruses, Vol. 15, Pages 1629: Multiple Porcine Innate Immune Signaling Pathways Are Involved in the Anti-PEDV Response
In this study, we observed that various porcine innate immune signaling adaptors are involved in anti-PEDV (AJ1102-like strain) activity in transfected Vero cells. Among these, TRIF and MAVS showed the strongest anti-PEDV activity. The endogenous TRIF, MAVS, and STING were selected for further examination of anti-PEDV activity. Agonist stimulation experiments showed that TRIF, MAVS, and STING signaling all have obvious anti-PEDV activity. The siRNA knockdown assay showed that TRIF, MAVS, and STING are also all involved in anti-PEDV response, and their remarkable effects on PEDV replication were confirmed in TRIF&mi...
Source: Viruses - July 26, 2023 Category: Virology Authors: Youwen Zhang Yulin Xu Sen Jiang Shaohua Sun Jiajia Zhang Jia Luo Qi Cao Wanglong Zheng Fran çois Meurens Nanhua Chen Jianzhong Zhu Tags: Article Source Type: research

Nicotine exacerbates diabetic nephropathy through upregulation of Grem1 expression
CONCLUSION: Grem1 plays a vital role in nicotine-exacerbated DN. Grem1 may be a potential therapeutic target for chronic smokers with DN.PMID:37415117 | DOI:10.1186/s10020-023-00692-9
Source: Molecular Medicine - July 6, 2023 Category: Molecular Biology Authors: Jianning Chen Haiting Xiao Rui Xue Vinod Kumar Rukhsana Aslam Syed Faizan Mehdi Huairong Luo Ashwani Malhotra Xiqian Lan Pravin Singhal Source Type: research

Antiviral and protective effect of small interfering RNAs against rift valley fever virus in vitro
CONCLUSION: Pre and post-transfection of siRNAs significantly reduced RVFV titer in cell lines, offering novel and potentially effective anti-RVFV epidemics and epizootics therapy.PMID:37231214 | DOI:10.1007/s11033-023-08455-9
Source: Molecular Biology Reports - May 25, 2023 Category: Molecular Biology Authors: Engy M Ahmed Abeer A Boseila Amro S Hanora Samar M Solyman Source Type: research

The novel Nsp9-interacting host factor H2BE promotes PEDV replication by inhibiting endoplasmic reticulum stress-mediated apoptosis
In conclusion, these studies revealed the mechanism by which H2BE is associated with ER stress-mediated apoptosis to regulate PEDV replication. Nsp9 upregulates H2BE. H2BE plays a role in inhibiting apoptosis and thus facilitating viral replication, whic h depends on the N-terminal region of H2BE (amino acids 1–28). These findings provide a reference for host–PEDV interactions and offer the possibility for developing strategies for PEDV decontamination and prevention.
Source: Veterinary Research - March 22, 2023 Category: Veterinary Research Source Type: research

N protein of PEDV plays chess game with host proteins by selective autophagy
In this study, we have found a novel host restriction factor, HNRNPA1, that could inhibit PEDV replication by degrading viral nucleocapsid (N) protein. The restriction factor activates the HNRNPA1-MARCHF8/MARCH8-CALCOCO2/NDP52-autophagosome pathway with the help of transcription factor EGR1 targeting the HNRNPA1 promoter. HNRNPA1 could also promote the expression of IFN to facilitate the host antiviral defense response for antagonizing PEDV infection through RIGI protein interaction. During viral replication, we found that PEDV can, in contrast, degrade the host antiviral proteins HNRNPA1 and others (FUBP3, HNRNPK, PTBP1, ...
Source: Autophagy - March 2, 2023 Category: Cytology Authors: Xueying Zhai Ning Kong Yu Zhang Yiyi Song Wenzhen Qin Xinyu Yang Chenqian Ye Manqing Ye Wu Tong Changlong Liu Hao Zheng Hai Yu Wen Zhang Xia Yang Gaiping Zhang Guangzhi Tong Tongling Shan Source Type: research

Long non-coding RNA SNHG9 regulates viral replication in rhabdomyosarcoma cells infected with enterovirus D68 via miR-150-5p/c-Fos axis
ConclusionOur findings indicate that the SNHG9/miR-150-5p/c-Fos axis influences EV-D68 replication in host cells and that SNHG9 may be a possible target for anti-EV-D68 infection therapies.
Source: Frontiers in Microbiology - January 19, 2023 Category: Microbiology Source Type: research

Dengue virus is involved in insulin resistance via the downregulation of IRS-1 by inducing TNF- α secretion
Biochim Biophys Acta Mol Basis Dis. 2022 Jun 22:166472. doi: 10.1016/j.bbadis.2022.166472. Online ahead of print.ABSTRACTDuring the epidemic, the individuals with underlying diseases usually have a higher rate of mortality. Diabetes is highly prevalent worldwide, making it a frequent comorbidity in dengue fever patients. Therefore, understanding the relationship between dengue virus (DENV) infection and diabetes is important. We first demonstrated that DENV-3 infection down-regulated the expression of IRS-1. In vitro, treatment of HepG2 cells with TNF-α inhibitors and siRNA proved that after DENV-3 infection in HepG2 cell...
Source: Biochimica et Biophysica Acta - June 25, 2022 Category: Biochemistry Authors: Xuling Liu Zuxin Liang Hongwei Duan Jianhai Yu Zhiran Qin Jingshu Li Li Zhu Qinghua Wu Weiwei Xiao Chenguang Shen Chengsong Wan Kefeng Wu Hua Ye Bao Zhang Wei Zhao Source Type: research

Viruses, Vol. 14, Pages 1196: Poly(A)-Binding Protein Cytoplasmic 1 Inhibits Porcine Epidemic Diarrhea Virus Replication by Interacting with Nucleocapsid Protein
ao Chunyi Xue Porcine epidemic diarrhea virus (PEDV) is the etiological agent of porcine epidemic diarrhea (PED) characterized by vomit, watery diarrhea, dehydration and high mortality. Outbreaks of highly pathogenic variant strains of PEDV have resulted in extreme economic losses to the swine industry all over the world. The study of host–virus interaction can help to better understand the viral pathogenicity. Many studies have shown that poly(A)-binding proteins are involved in the replication process of various viruses. Here, we found that the infection of PEDV downregulated the expression of poly(A)...
Source: Viruses - May 31, 2022 Category: Virology Authors: Tingting Wu Xiaona Wei Shumei Zheng Gaoli She Zhenling Han Zhichao Xu Yongchang Cao Chunyi Xue Tags: Article Source Type: research

Drug repurposing of dextromethorphan as a cellular target for the management of influenza
ConclusionInfluenza viruses continue to emerge and cause infection (including pandemics) in humans, so there remains a critical need to advance the understanding of influenza treatment. Our results demonstrated reduced hospitalization rates for influenza patients treated with DM. Further research on cellular targets and / or DM are warranted for the treatment of influenza.
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - August 24, 2021 Category: Drugs & Pharmacology Authors: Tammy H. Cummings, Joseph Magagnoli, James W. Hardin, S. Scott Sutton Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Molecules, Vol. 26, Pages 4919: The Inhibitory Effect of Sulforaphane on Bladder Cancer Cell Depends on GSH Depletion-Induced by Nrf2 Translocation
In this study, human bladder cancer T24 cells were used as in vitro model for revealing the inhibitory effect and its potential mechanism of SFN on cell growth. Here, a low dose of SFN (2.5 µM) was shown to promote cell proliferation (5.18–11.84%) and migration in T24 cells, whilst high doses of SFN (>10 µM) inhibited cell growth significantly. The induction effect of SFN on nuclear factor (erythroid-derived 2)-like 2 (Nrf2) expression at both low (2.5 µM) and high dose (10 µM) was characterized by a bell-shaped curve. Nrf2 and glutathione (GSH) might be the underlying mechanism in the effect of SFN on T24...
Source: Molecules - August 13, 2021 Category: Chemistry Authors: Canxia He Luigina P. Buongiorno Wei Wang Jonathan C. Y. Tang Natalizia Miceli Maria Fernanda Taviano Yujuan Shan Yongping Bao Tags: Article Source Type: research

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