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Helicobacter pylori induces Snail expression through ROS‐mediated activation of Erk and inactivation of GSK‐3β in human gastric cancer cells
Helicobacter pylori (H. pylori) infection has been known to be implicated in human gastric carcinogenesis. Snail, the zinc‐finger transcription factor known as a key inducer of changes in the cell shape and morphogenetic movement, is aberrantly overexpressed and correlates with lymph node metastasis in gastric cancer. In the present study, we investigated whether H. pylori could induce Snail activation to provoke these changes. Using a cell scatter assay, we noticed that human gastric cancer AGS cells infected with H. pylori underwent morphological changes as well as disruption of cell–cell interaction, which was then ...
Source: Molecular Carcinogenesis - January 26, 2016 Category: Molecular Biology Authors: Hoang‐Kieu‐Chi Ngo, Hee Geum Lee, Juan‐Yu Piao, Xiancai Zhong, Ha‐Na Lee, Hyeong‐Jun Han, Wonki Kim, Do‐Hee Kim, Young‐Nam Cha, Hye‐Kyung Na, Young‐Joon Surh Tags: Research Article Source Type: research

Helicobacter pylori induces Snail expression through ROS ‐mediated activation of Erk and inactivation of GSK‐3β in human gastric cancer cells
Helicobacter pylori (H. pylori) infection has been known to be implicated in human gastric carcinogenesis. Snail, the zinc‐finger transcription factor known as a key inducer of changes in the cell shape and morphogenetic movement, is aberrantly overexpressed and correlates with lymph node metastasis in gastric cancer. In the present study, we investigated whether H. pylori could induce Snail activation to provoke these changes. Using a cell scatter assay, we noticed that human gastric cancer AGS cells infected with H. pylori underwent morphological changes as well as disruption of cell–cell interaction, which was then ...
Source: Molecular Carcinogenesis - January 24, 2016 Category: Molecular Biology Authors: Hoang ‐Kieu‐Chi Ngo, Hee Geum Lee, Juan‐Yu Piao, Xiancai Zhong, Ha‐Na Lee, Hyeong‐Jun Han, Wonki Kim, Do‐Hee Kim, Young‐Nam Cha, Hye‐Kyung Na, Young‐Joon Surh Tags: Research Article Source Type: research