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Source: International Journal of Biological Macromolecules
Infectious Disease: Dengue Fever
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Dengue virus induced autophagy is mediated by HMGB1 and promotes viral propagation
This study shows that the modulation of autophagy by DENV-2 is HMGB1/BECN1 dependent. In addition, glycyrrhizic acid (GA), a potent HMGB1 inhibitor suppressed autophagy as well as DENV-2 replication. Altogether, our data suggests that HMGB1 induces BECN1 dependent autophagy to promote DENV-2 replication.PMID:36587643 | DOI:10.1016/j.ijbiomac.2022.12.299
Source: International Journal of Biological Macromolecules - January 1, 2023 Category: Biochemistry Authors: Nidhi Chaudhary Shikha Srivastava Sunny Gupta Manoj B Menon Ashok Kumar Patel Source Type: research
