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A potential link between TSLP/TSLPR/STAT5 and TLR2/MyD88/NFκB-p65 in human corneal epithelial cells for Aspergillus fumigatus tolerance
Publication date: March 2016 Source:Molecular Immunology, Volume 71 Author(s): Xiaoxiao Ren, Leyi Wang, Xinyi Wu Our previous studies reported that pattern recognition receptors (PRRs), including the cell surface Toll-like receptors (TLRs) and cytoplasmic NOD-like receptors (NLRs), recognize pathogen-associated molecular patterns (PAMPS) to initiate downstream signal cascades to active immunity responses. Thymic stromal lymphopoietin (TSLP) has recently emerged as a key cytokine in the development of type 2 adaptive immune responses. However, the crosstalk between PRRs and TSLP has not been well elucidated in Aspergil...
Source: Molecular Immunology - February 12, 2016 Category: Allergy & Immunology Source Type: research

The crosstalk between TLR2 and NOD2 in Aspergillus fumigatus keratitis
Publication date: April 2015 Source:Molecular Immunology, Volume 64, Issue 2 Author(s): Jiayin Wu , Yuting Zhang , Zhaoting Xin , Xinyi Wu Innate immunity is considered to be critical in the pathogenesis of fungal keratitis. Pattern recognition receptors (PRRs) recognize conserved microbial structures called pathogen-associated molecular patterns (PAMPS), thereby initiating the innate immunity. Toll-like receptors (TLRs) and nucleotide-binding oligomerization domain (NOD)-like receptors (leucine-rich repeat-containing receptors, NLRs) are two major PRR families. The crosstalk between TLR2 and NOD2 is not completely under...
Source: Molecular Immunology - January 1, 2015 Category: Allergy & Immunology Source Type: research