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Source: Current Eye Research
Infectious Disease: Aspergillus
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Glabridin Inhibits < em > Aspergillus fumigatus < /em > Growth and Alleviate Inflammation Mediated by Dectin-2 and NLRP3 Inflammasome
CONCLUSION: Glabridin plays an anti-inflammatory role in A. fumigatus challenge via suppression of the Dectin-2 and NLRP3 inflammasome, and plays an anti-fungal role through delaying germination and changing the hyphal integrity.KEY MESSAGESGlabridin plays an anti-inflammatory role in A. fumigatus infection of RAW264.7 cells in a concentration-dependent manner and through Dectin-2 mediation.Glabridin decreases fungal distribution and inflammation in mouse A. fumigatus keratitis.Glabridin inhibits A. fumigatus growth by delaying germination and disrupting cellular structure in vitro.PMID:36785524 | DOI:10.1080/02713683.2022.2164779
Source: Current Eye Research - February 14, 2023 Category: Opthalmology Authors: Lu Zhan Xue Tian Jing Lin Xudong Peng Guiqiu Zhao Source Type: research
