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Source: European Review for Medical and Pharmacological Sciences
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Total 305 results found since Jan 2013.
Long non-coding RNA CACNA1G-AS1 promotes cell migration, invasion and epithelial-mesenchymal transition by HNRNPA2B1 in non-small cell lung cancer.
CONCLUSIONS: CACNA1G-AS1 was identified as an oncogene in NSCLC for the first time, and could promote cell invasion, migration and EMT via increasing HNRNPA2B1 expression, providing a novel target for the biological therapy and prevention.
PMID: 29509247 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - March 8, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Long non-coding RNA GAS5 contributed to the development of glaucoma via regulating the TGF- β signaling pathway.
CONCLUSIONS: In our study, we found that down-regulation of lncRNA GAS5 may maintain retinal ganglion cell survival in glaucoma through the activation of TGF-β pathway to promote cell proliferation and differentiation.
PMID: 29509235 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - March 8, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Long non-coding RNA BANCR indicates poor prognosis for breast cancer and promotes cell proliferation and invasion.
CONCLUSIONS: LncRNA BANCR is highly expressed in breast cancer, which is significantly correlated with the prognosis of patients; moreover, it can promote the growth, invasion and metastasis of ovarian cancer cells. The down-regulation of BANCR can inhibit the proliferation, invasion and metastasis capacities of MCF-7 cells.
PMID: 29565494 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - March 24, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Long noncoding RNA Lnc01614 promotes the occurrence and development of gastric cancer by activating EMT pathway.
CONCLUSIONS: Lnc01614 was upregulated in gastric cancer and significantly correlated with gastric cancer staging, lymph node metastasis, distant metastasis and poor prognosis. Lnc01614 may promote the proliferation, invasion and migration capabilities of gastric cancer through the regulation of epithelial-mesenchymal transition (EMT) pathway.
PMID: 29565488 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - March 24, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
MicroRNA-338 inhibits proliferation, migration, and invasion of gastric cancer cells by the Wnt/ β-catenin signaling pathway.
CONCLUSIONS: This study indicated that miR-338 is a potential tumor suppressor in gastric cancer and miR-338 inhibited EMT of gastric cancer cells through deactivation of Wnt/β-catenin signaling targeting at EphA2.
PMID: 29565486 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - March 24, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
MMP-14 aggravates onset of severe preeclampsia by mediating soluble endoglin release.
CONCLUSIONS: MMP-14 aggravated the onset of severe preeclampsia by mediating sEng release. MMP-14 was proposed as the effective target for the treatment of severe preeclampsia. Blocking the interaction between MMP-14 and endothelial protein may be an important treatment method.
PMID: 29565476 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - March 24, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Effects of long non-coding RNA URHC on proliferation, apoptosis and invasion of colorectal cancer cells.
CONCLUSIONS: Down-regulation of lncRNA-URHC can inhibit the progression of colorectal cancer.
PMID: 29630109 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - April 10, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
LINC00963 promotes hepatocellular carcinoma progression by activating PI3K/AKT pathway.
CONCLUSIONS: Our data revealed that LINC00963 was upregulated in HCC, which significantly extended the G0/G1 phase of HCC cells by activating PI3K/AKT pathway and promoting the proliferative ability of HCC cells. LINC00963 may be involved in the HCC development.
PMID: 29630107 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - April 10, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
MiR-1908 improves cardiac fibrosis after myocardial infarction by targeting TGF- β1.
CONCLUSIONS: MiR-1908 can improve the myocardial fibrosis through the target gene TGF-β1.
PMID: 29687863 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - April 26, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
MiR-154 promotes myocardial fibrosis through β-catenin signaling pathway.
CONCLUSIONS: MiR-154 can inhibit GSK-3β expression by activating Wnt/β-catenin signaling pathway, which promotes myocardial fibrosis.
PMID: 29687862 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - April 26, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
MiR-17-5p promotes cervical cancer cell proliferation and metastasis by targeting transforming growth factor- β receptor 2.
CONCLUSIONS: MiR-17-5p enhances cervical cancer proliferation and metastasis via targeting TGFBR2. It is proposed that targeting miR-17-5p may be a promising therapeutic approach for cervical cancer.
PMID: 29687841 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - April 26, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Long non-coding RNA DUXAP8 regulates proliferation and invasion of esophageal squamous cell cancer.
CONCLUSIONS: DUXAP8 expression was significantly correlated with tumor stage, lymph node metastasis and poor prognosis of ESCC patients. DUXAP8 may promote the occurrence of ESCC via Wnt/β-catenin pathway.
PMID: 29771416 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - May 19, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
LncRNA FAS-AS1 promotes the degradation of extracellular matrix of cartilage in osteoarthritis.
CONCLUSIONS: The expression of FAS-AS1 was increased in osteoarthritis, and FAS-AS1 could be involved in the development of the disease by regulating the proliferation, apoptosis of chondrocytes and promoting the degradation of extracellular matrix.
PMID: 29863238 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - June 8, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Sestrin2 aggravates oxidative stress of neurons by decreasing the expression of Nrf2.
CONCLUSIONS: Sesn2 promoted the transfer of nuclear Nrf2 to the cytoplasm, it decreased the expressions of Nrf2 and its downstream proteins, Srx1 and Trx1. Meanwhile, it increased the cerebral ischemia-reperfusion injury by changing the distribution of Nrf2.
PMID: 29917204 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - June 20, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
The role of MiR-324-3p in polycystic ovary syndrome (PCOS) via targeting WNT2B.
CONCLUSIONS: The expression of miR-324-3p in the ovary of PCOS rats is decreased significantly. Overexpression of miR-324-3p can reduce the proliferation and induce the apoptosis of granulosa cells via targeting of WNT2B.
PMID: 29917177 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - June 20, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
