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Source: Experimental and Therapeutic Medicine
Therapy: Stem Cell Therapy
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Total 23 results found since Jan 2013.
Transplantation of IL-1 β siRNA-modified bone marrow mesenchymal stem cells ameliorates type II collagen-induced rheumatoid arthritis in rats
Exp Ther Med. 2022 Feb;23(2):139. doi: 10.3892/etm.2021.11062. Epub 2021 Dec 14.ABSTRACTRheumatoid arthritis (RA) is a chronic autoimmune disease that causes erosion of articular cartilage and bone and has adverse effects on both patients and livestock animals. The aim of the present study was to investigate the role of interleukin-1β (IL-1β) in the pathogenesis of RA, and to further determine whether injection of IL-1β small interfering RNA (siRNA) or transplantation of IL-1β siRNA + bone marrow mesenchymal stem cells (BMSCs) can ameliorate RA in rats. A collagen-induced arthritis (CIA) rat model was established by in...
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Shifeng Pan Xuan Dong Yan Wang Tiansheng Zhou Yuting Liu An Zhou Hua Xing Source Type: research
Autophagy is involved in neurofibromatosis type I gene-modulated osteogenic differentiation in human bone mesenchymal stem cells
In conclusion, results from the present study suggest at the involvement of autophagy in the NF1-modulated osteogenic differentiation of BMSCs. Furthermore, NF1 may partially regulate the autophagic activity of BMSCs through the PI3K/AKT/mTOR signaling pathway.PMID:34603530 | PMC:PMC8453340 | DOI:10.3892/etm.2021.10697
Source: Experimental and Therapeutic Medicine - October 4, 2021 Category: General Medicine Authors: Yiqiang Li Mingwei Zhu Xuemei Lin Jingchun Li Zhe Yuan Yanhan Liu Hongwen Xu Source Type: research
Insulin growth factor-1 promotes the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells through the Wnt/ β-catenin pathway
Exp Ther Med. 2021 Aug;22(2):891. doi: 10.3892/etm.2021.10323. Epub 2021 Jun 17.ABSTRACTBone marrow mesenchymal stem cells (BMSCs) are stem cells that exist in bone marrow tissue and have osteogenic differentiation potential. Insulin growth factor-1 (IGF-1) plays a key role in the proliferation and osteogenic differentiation of BMSCs. However, the specific mechanism of IGF-1 in cell proliferation and osteogenic differentiation remains unclear. In the present study, BMSCs were transfected with lentivirus carrying the siRNA-Wnt3a gene, and the Wnt3a level in BMSCs was revealed to be reduced by western blotting, real-time qua...
Source: Experimental and Therapeutic Medicine - July 1, 2021 Category: General Medicine Authors: Jing Feng Zhiqiang Meng Source Type: research
