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Inhibition of aquaporins as a potential adjunct to breast cancer cryotherapy
Oncol Lett. 2021 Jun;21(6):458. doi: 10.3892/ol.2021.12719. Epub 2021 Apr 8.ABSTRACTCryoablation is an emerging type of treatment for cancer. The sensitization of tumors using cryosensitizing agents prior to treatment enhances ablation efficiency and may improve clinical outcomes. Water efflux, which is regulated by aquaporin channels, contributes to cancer cell damage achieved through cryoablation. An increase in aquaporin (AQP) 3 is cryoprotective, whereas its inhibition augments cryodamage. The present study aimed to investigate aquaporin (AQP1, AQP3 and AQP5) gene expression and cellular localization in response to cry...
Source: Oncology Letters - April 28, 2021 Category: Cancer & Oncology Authors: Haifa Alkhalifa Fatima Mohammed Sebastien Taurin Khaled Greish Safa Taha Salim Fredericks Source Type: research