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Source: Oncology Letters
Condition: Pulmonary Hypertension
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Total 1 results found since Jan 2013.
Effect of miR-23a on anoxia-induced phenotypic transformation of smooth muscle cells of rat pulmonary arteries and regulatory mechanism.
Authors: Yan L, Gao H, Li C, Han X, Qi X
Abstract
We investigated the possible implication of miR-23a in anoxia-induced phenotypic transformation of the pulmonary arterial smooth muscle and studied the mechanism of upregulation of miR-23a expression in anoxia. The collagenase digestion method was used for preparing rat primary pulmonary artery smooth muscle cell (PASMC) culture. SM-MHC, SM-α-actin, calponin-1 and SM22α protein expression levels were evaluated using western blot analysis after the ASMCs were subjected to anoxia treatment (3% O2). Transfection with miR-23a mimics were conducted when PASMCs were und...
Source: Oncology Letters - January 28, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
