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Source: Molecules
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Total 109 results found since Jan 2013.
Molecules, Vol. 20, Pages 13055-13070: Cell-Type Specific Penetrating Peptides: Therapeutic Promises and Challenges
Cell penetrating peptides (CPP), also known as protein transduction domains (PTD), are small peptides able to carry peptides, proteins, nucleic acid, and nanoparticles, including viral particles, across the cellular membranes into cells, resulting in internalization of the intact cargo. In general, CPPs can be broadly classified into tissue-specific and non-tissue specific peptides, with the latter further sub-divided into three types: (1) cationic peptides of 6–12 amino acids in length comprised predominantly of arginine, lysine and/or ornithine residues; (2) hydrophobic peptides such as leader sequences of secreted gro...
Source: Molecules - July 20, 2015 Category: Chemistry Authors: Maliha ZahidPaul Robbins Tags: Review Source Type: research
Molecules, Vol. 20, Pages 7602-7619: Modulation of the RNA Interference Activity Using Central Mismatched siRNAs and Acyclic Threoninol Nucleic Acids (aTNA) Units
In this study, we investigate the potential correlations between the thermodynamic and silencing properties of siRNA molecules carrying, at internal positions, an acyclic L-threoninol nucleic acid (aTNA) modification. Depending on position, the silencing is weakened or impaired. Furthermore, we evaluate the contribution of mismatches facing either a natural nucleotide or an aTNA modification to the siRNA potency. The position 11 of the antisense strand is more permissive to mismatches and aTNA modification, in respect to the position 10. Additionally, comparing the ON-/OFF-target silencing of central mismatched siRNAs with...
Source: Molecules - April 24, 2015 Category: Chemistry Authors: Adele AlagiaMontserrat TerrazasRamon Eritja Tags: Article Source Type: research
Molecules, Vol. 20, Pages 4020-4041: Hybridisation Potential of 1',3'-Di-O-methylaltropyranoside Nucleic Acids
In further study of our series of six-membered ring-containing nucleic acids, different 1',3'-di-O-methyl altropyranoside nucleoside analogs (DMANA) were synthesized comprising all four base moieties, adenine, cytosine, uracil and guanine. Following assembly into oligonucleotides (ONs), their affinity for natural oligonucleotides was evaluated by thermal denaturation of the respective duplexes. Data were compared with results obtained previously for both anhydrohexitol (HNAs) and 3'-O-methylated altrohexitol modified ONs (MANAs). We hereby demonstrate that ONs modified with DMANA monomers, unlike some of our previously des...
Source: Molecules - March 3, 2015 Category: Chemistry Authors: Akkaladevi VenkateshamDhuldeo KachareGuy SchepersJef RozenskiMathy FroeyenArthur Van Aerschot Tags: Article Source Type: research
Molecules, Vol. 19, Pages 17872-17896: RNA/aTNA Chimeras: RNAi Effects and Nucleases Resistance of Single and Double Stranded RNAs
The RNA interference pathway (RNAi) is a specific and powerful biological process, triggered by small non-coding RNA molecules and involved in gene expression regulation. In this work, we explored the possibility of increasing the biological stability of these RNA molecules by replacing their natural ribose ring with an acyclic L-threoninol backbone. In particular, this modification has been incorporated at certain positions of the oligonucleotide strands and its effects on the biological properties of the siRNA have been evaluated. In vitro cellular RNAi assays have demonstrated that the L-threoninol backbone is well tole...
Source: Molecules - November 4, 2014 Category: Chemistry Authors: Adele AlagiaMontserrat TerrazasRamon Eritja Tags: Article Source Type: research
