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Molecules, Vol. 25, Pages 6028: The Antiasthma Medication Ciclesonide Suppresses Breast Cancer Stem Cells through Inhibition of the Glucocorticoid Receptor Signaling-Dependent YAP Pathway
This study focused on investigating the effect of ciclesonide on breast cancer and CSCs and determining its underlying mechanism. Here, we showed that ciclesonide inhibits breast cancer and CSC formation. Similar glucocorticoids—dexamethasone and prednisone—did not inhibit CSC formation. Ciclesonide-induced glucocorticoid receptor (GR) degradation was dependent on ubiquitination. We showed via GR small interfering RNA (siRNA) that GR plays an important role in CSC formation. We showed via western blot and immunofluorescence assays that ciclesonide reduces the nuclear level of GR. The GR antagoni...
Source: Molecules - December 19, 2020 Category: Chemistry Authors: Su-Lim Kim Hack Sun Choi Ji-Hyang Kim Dong-Sun Lee Tags: Article Source Type: research

Molecules, Vol. 22, Pages 139: Oligonucleotide Therapy for Obstructive and Restrictive Respiratory Diseases
Inhaled oligonucleotide is an emerging therapeutic modality for various common respiratory diseases, including obstructive airway diseases like asthma and chronic obstructive pulmonary disease (COPD) and restrictive airway diseases like idiopathic pulmonary fibrosis (IPF). The advantage of direct accessibility for oligonucleotide molecules to the lung target sites, bypassing systemic administration, makes this therapeutic approach promising with minimized potential systemic side effects. Asthma, COPD, and IPF are common chronic respiratory diseases, characterized by persistent airway inflammation and dysregulated tissue re...
Source: Molecules - January 16, 2017 Category: Chemistry Authors: Wupeng Liao Jinrui Dong Hong Peh Lay Tan Kah Lim Li Li Wai-Shiu Wong Tags: Review Source Type: research