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HAX-1 inhibits apoptosis in prostate cancer through the suppression of caspase-9 activation.
Authors: Yan J, Ma C, Cheng J, Li Z, Liu C Abstract HS1 associated protein X-1 (HAX-1), a substrate of Src family tyrosine kinases, plays a critical role in cell apoptosis. However, its functions in prostate cancer remains unclear. The present study explored the role and mechanism of HAX-1 in cancer cell apoptosis. The mRNA and protein levels of HAX-1 in the prostate cancer cell lines PC-3, VCaP and DU145 were assessed. Cell proliferation, apoptosis and caspase-9 activities were assessed in DU145 after HAX-1 siRNA treatment. The mRNA and protein levels of HAX-1 in prostate cancer cell lines PC-3, VCaP and DU145 wer...
Source: Oncology Reports - September 3, 2015 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research