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Cx32 inhibits TNF α-induced extrinsic apoptosis with and without EGFR suppression.
Cx32 inhibits TNFα-induced extrinsic apoptosis with and without EGFR suppression. Oncol Rep. 2017 Sep 07;: Authors: Lai Y, Tao L, Zhao Y, Zhang X, Sun X, Wang Q, Xu C Abstract Tumor necrosis factor α (TNFα) and TNF-related apoptosis-inducing ligand (TRAIL) can trigger the extrinsic apoptosis pathway. Our previous study indicated that connexin32 (Cx32) inhibited streptonigrin-induced intrinsic apoptosis via the epidermal growth factor receptor (EGFR) pathway. However, whether Cx32 can exert effects on the extrinsic apoptosis pathway through EGFR signaling remains unclear. In the present study, we inv...
Source: Oncology Reports - September 14, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research