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Retracted Synergistic effects of co ‑expression plasmid‑based ADAM10‑specific siRNA and GRIM‑19 on hepatocellular carcinoma < em > in  vitro < /em > and < em > in  vivo < /em >
Oncol Rep. 2022 Feb;47(2):24. doi: 10.3892/or.2021.8235. Epub 2021 Nov 29.ABSTRACTFollowing the publication of the above paper, it was drawn to the Editor's attention by a concerned reader that various data featured in several of the figures were strikingly similar to data appearing in different form in other articles by different authors. An independent enquiry was launched by the Editorial Office, which revealed that cell migration assay data featured in Fig. 5A and C of the above article had been included in another article written by different authors submitted for publication some 12 months previously. Owing to the fa...
Source: Oncology Reports - November 29, 2021 Category: Cancer & Oncology Authors: Songyang Liu Wei Zhang Kai Liu Yingchao Wang Bai Ji Yahui Liu Source Type: research

Corrigendum MicroRNA ‑122 affects cell aggressiveness and apoptosis by targeting PKM2 in human hepatocellular carcinoma
Oncol Rep. 2021 Jul;46(1):122. doi: 10.3892/or.2021.8073. Epub 2021 May 13.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that Figs. 6C and 7A apparently contained overlapping panels, suggesting that these data for purportedly different experiments had been derived from the same original source. The wound‑healing result for the anti‑miR‑122+siRNA PKM2 experiment in the lower panel of Fig. 6C and the transwell invasion result for the anti‑miR‑122+siRNA PKM2 experiment in Fig. 7A were erroneously selected. Accordingly, the authors repeated these assays an...
Source: Oncology Reports - May 13, 2021 Category: Cancer & Oncology Authors: Qiuran Xu Meiqi Zhang Jianfeng Tu Linxiao Pang Wenwei Cai Xin Liu Source Type: research

Involvement of RNase 7 in the malignant potential of oral squamous cell carcinoma cells.
Authors: Neopane P, Kurashige Y, Yoshida K, Uehara O, Paudel D, Morikawa T, Sato J, Saitoh M, Abiko Y Abstract RNase 7 is involved in the innate immunity of the oral epithelium. Variations in the expression levels of RNase 7 have been reported in cutaneous squamous cell carcinoma, but not in oral squamous cell carcinoma (OSCC). The present study investigated the expression levels of RNase 7 in OSCC and its role in the malignant potential of these cells. The localization of RNase 7 in OSCC tissue sections was determined via immunohistochemistry. Positive staining for RNase 7 was observed around the epithelial pearls...
Source: Oncology Reports - July 28, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Long non ‑coding RNA H19 is involved in sorafenib resistance in hepatocellular carcinoma by upregulating miR‑675.
In conclusion, our study provides new clues for further clinical treatment of sorafenib‑resistant liver cancer patients. PMID: 32627034 [PubMed - as supplied by publisher]
Source: Oncology Reports - July 7, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Tumor necrosis factor ‑related apoptosis‑inducing ligand as a therapeutic option in urothelial cancer cells with acquired resistance against first‑line chemotherapy.
Tumor necrosis factor‑related apoptosis‑inducing ligand as a therapeutic option in urothelial cancer cells with acquired resistance against first‑line chemotherapy. Oncol Rep. 2020 Feb 03;: Authors: Vallo S, Stege H, Berg M, Michaelis M, Winkelmann R, Rothweiler F, Cinatl J Abstract Patients with urothelial carcinoma frequently fail to respond to first‑line chemotherapy using cisplatin and gemcitabine due to development of resistant tumor cells. The aim of the present study was to investigate whether an alternative treatment with tumor necrosis factor‑related apoptosis‑inducing ligand (TRAI...
Source: Oncology Reports - February 7, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Downregulation of MUTYH contributes to cisplatin ‑resistance of esophageal squamous cell carcinoma cells by promoting Twist‑mediated EMT.
In conclusion, the present data demonstrated that EMT activation mediated by MUTYH downregulation, by both enhancing Twist transcription and blocking its degradation, is one of the mechanisms for acquisition of CDDP resistance in ESCC. PMID: 31578574 [PubMed - as supplied by publisher]
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

LINC00461 affects the survival of patients with renal cell carcinoma by acting as a competing endogenous RNA for microRNA ‑942.
LINC00461 affects the survival of patients with renal cell carcinoma by acting as a competing endogenous RNA for microRNA‑942. Oncol Rep. 2019 Sep 12;: Authors: Chen Y, He J, Su C, Wang H, Chen Y, Guo W, Li Y, Ding G Abstract The present study aimed to investigate the potential mechanisms of human miR‑942 in the sunitinib‑resistance of renal cell carcinoma (RCC). A sunitinib‑resistant OS‑RC‑2 cell line was established by continuous exposure to increasing concentrations of sunitinib for ~12 weeks. The expression levels of four miRNAs were determined by reverse transcription‑quantitative (...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Curcumin decreases epithelial ‑mesenchymal transition by a Pirin‑dependent mechanism in cervical cancer cells.
Curcumin decreases epithelial‑mesenchymal transition by a Pirin‑dependent mechanism in cervical cancer cells. Oncol Rep. 2019 Aug 21;: Authors: Aedo-Aguilera V, Carrillo-Beltrán D, Calaf GM, Muñoz JP, Guerrero N, Osorio JC, Tapia JC, León O, Contreras HR, Aguayo F Abstract Curcumin is a natural antioxidant polyphenol, which decreases epithelial‑mesenchymal transition (EMT) and cell migration in cervical cancer cells. However, the mechanism by which such a decrease occurs is unclear. It is well established that cervical cancer can be caused by high‑risk human papillomavirus (HPV), which ove...
Source: Oncology Reports - August 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

TNF ‑α‑mediated upregulation of SOD‑2 contributes to cell proliferation and cisplatin resistance in esophageal squamous cell carcinoma.
TNF‑α‑mediated upregulation of SOD‑2 contributes to cell proliferation and cisplatin resistance in esophageal squamous cell carcinoma. Oncol Rep. 2019 Jul 26;: Authors: Zuo J, Zhao M, Liu B, Han X, Li Y, Wang W, Zhang Q, Lv P, Xing L, Shen H, Zhang X Abstract Intrinsic and acquired resistance of cancer to radio‑and chemotherapy is one of the major challenges in the treatment of esophageal squamous cell carcinoma (ESCC). Elevated reactive oxygen species (ROS) play an important role in the resistance to cisplatin in ESCCs. Super dismutase [Mn], mitochondrial (SOD‑2), an important primary antio...
Source: Oncology Reports - August 1, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Keratin 6, induced by chronic cisplatin exposure, confers chemoresistance in human gastric carcinoma cells.
Authors: Lim SC, Parajuli KR, Han SI Abstract Currently, various types of keratins have been reported to be highly expressed in cancer cells and to be associated with a malignant phenotype. In the present study, it was found that expression levels of keratin 6 (K6), keratin 16 (K16), and keratin 17 (K17) were highly elevated in SNU601 cells resistant to cisplatin (SNU601‑cis2 and SNU601‑cis10), but not in the parental SNU601 cells as confirmed by quantitative PCR, immunoblotting, and immunofluorescence assays. K6 is a type II keratin and is known to form a keratin filament in conjugation with type I keratin, K1...
Source: Oncology Reports - June 25, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

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