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Source: PLoS One
Drug: Insulin
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Total 3 results found since Jan 2013.
CREG1 heterozygous mice are susceptible to high fat diet-induced obesity and insulin resistance
This study uncovered a novel function of CREG1 in metabolic disorders.
Source: PLoS One - May 1, 2017 Category: Biomedical Science Authors: Xiaoxiang Tian Source Type: research
A Convenient < i > In Vivo < /i > Model Using Small Interfering RNA Silencing to Rapidly Assess Skeletal Gene Function
by Wen Zhang, Can Liu, Bao Hai, Guohong Du, Hong Wang, Huijie Leng, Yingsheng Xu, Chunli Song
It is difficult to study bone in vitro because it contains various cell types that engage in cross-talk. Bone biologically links various organs, and it has thus become increasingly evident that skeletal physiology must be studied in an integrative manner in an intact animal. We developed a model u sing local intraosseous small interfering RNA (siRNA) injection to rapidly assess the effects of a target gene on the local skeletal environment. In this model, 160-g male Sprague-Dawley rats were treated for 1–2 weeks. The left tibia...
Source: PLoS One - November 27, 2016 Category: Biomedical Science Authors: Wen Zhang Source Type: research
Ampelopsin Improves Insulin Resistance by Activating PPARγ and Subsequently Up-Regulating FGF21-AMPK Signaling Pathway
by Yong Zhou, Ying Wu, Yu Qin, Lei Liu, Jing Wan, Lingyun Zou, Qianyong Zhang, Jundong Zhu, Mantian Mi
Ampelopsin (APL), a major bioactive constituent of Ampelopsis grossedentata, exerts a number of biological effects. Here, we explored the anti-diabetic activity of APL and elucidate the underlying mechanism of this action. In palmitate-induced insulin resistance of L6 myotubes, APL treatment markedly up- regulated phosphorylated insulin receptor substrate-1 and protein kinase B, along with a corresponding increase of glucose uptake capacity. APL treatment also increased expressions of fibroblast growth factor (FGF21) and...
Source: PLoS One - July 7, 2016 Category: Biomedical Science Authors: Yong Zhou Source Type: research
