Filtered By:
Source: PLoS One
Condition: Alcoholism
This page shows you your search results in order of date.
Order by Relevance | Date
Total 1 results found since Jan 2013.
p53 pathway determines the cellular response to alcohol-induced DNA damage in MCF-7 breast cancer cells
by Ming Zhao, Erin W. Howard, Zhiying Guo, Amanda B. Parris, Xiaohe Yang
Alcohol consumption is associated with increased breast cancer risk; however, the underlying mechanisms that contribute to mammary tumor initiation and progression are unclear. Alcohol is known to induce oxidative stress and DNA damage; likewise, p53 is a critical modulator of the DNA repair pathw ay and ensures genomic integrity. p53 mutations are frequently detected in breast and other tumors. The impact of alcohol on p53 is recognized, yet the role of p53 in alcohol-induced mammary carcinogenesis remains poorly defined. In our study, we measured a...
Source: PLoS One - April 3, 2017 Category: Biomedical Science Authors: Ming Zhao Source Type: research
