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Source: PLoS One
Condition: Osteoporosis
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Total 1 results found since Jan 2013.
MicroRNA-433-3p promotes osteoblast differentiation through targeting DKK1 expression
In this study, mouse primary bone marrow cells and osteoblast cell lines were used. Lucifer ase reporter assay and western blotting methods were employed to validate if miRNA-433-3p epigenetically regulated DKK1 translation. Rat bone marrow derived osteoblasts were infected with lentivirus vector in which miR-433-3p was constructed. The authors constructed lentivirus mediated miRNA-433-3p stable expression and examined the alkaline phosphatase (ALP) activity and mineral deposition level in vitro. In situ hybridization method was used to observe miR-433-3p in primary osteoblasts. We built up an OVX rat model to mimic postme...
Source: PLoS One - June 19, 2017 Category: Biomedical Science Authors: Xiaolin Tang Source Type: research
