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Source: PLoS One
Condition: Cystic Fibrosis
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Total 1 results found since Jan 2013.
Sphingosine-1-Phosphate Is a Novel Regulator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity
by Firhan A. Malik, Anja Meissner, Illya Semenkov, Steven Molinski, Stan Pasyk, Saumel Ahmadi, Hai H. Bui, Christine E. Bear, Darcy Lidington, Steffen-Sebastian Bolz
The cystic fibrosis transmembrane conductance regulator (CFTR) attenuates sphingosine-1-phosphate (S1P) signaling in resistance arteries and has emerged as a prominent regulator of myogenic vasoconstriction. This investigation demonstrates that S1P inhibits CFTR activity via adenosine monophosphate-activated kinase (AMPK), establishing a potential feedback link. In Baby Hamster Kidney (BHK) cells expressing wild-type human CFTR, S1P (1μmol/L) attenuates fors...
Source: PLoS One - June 16, 2015 Category: Biomedical Science Authors: Firhan A. Malik et al. Source Type: research
