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Source: PLoS One
Condition: Cirrhosis
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Lipopolysaccharide (LPS)-Induced Biliary Epithelial Cell NRas Activation Requires Epidermal Growth Factor Receptor (EGFR)
by Christy E. Trussoni, James H. Tabibian, Patrick L. Splinter, Steven P. O’Hara
Cholangiocytes (biliary epithelial cells) actively participate in microbe-induced proinflammatory responses in the liver and contribute to inflammatory and infectious cholangiopathies. We previously demonstrated that cholangiocyte TLR-dependent NRas activation contributes to proinflammatory/ proliferative responses. We test the hypothesis that LPS-induced activation of NRas requires the EGFR. SV40-transformed human cholangiocytes (H69 cells), or low passage normal human cholangiocytes (NHC), were treated with LPS in the presence or absence ...
Source: PLoS One - April 27, 2015 Category: Biomedical Science Authors: Christy E. Trussoni et al. Source Type: research
