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Differential effects of < i > WRAP53 < /i > transcript variants on non-small cell lung cancer cell behaviors
ConclusionsWRAP53 transcript variants exerted different functions in non-small cell lung cancer cells and regulated non-small cell lung cancer cell behaviors depending on the p53 expression.
Source: PLoS One - January 27, 2023 Category: Biomedical Science Authors: Yan Zhu Source Type: research

TASK-1 Regulates Apoptosis and Proliferation in a Subset of Non-Small Cell Lung Cancers
by Katharina Leithner, Birgit Hirschmugl, Yingji Li, Bi Tang, Rita Papp, Chandran Nagaraj, Elvira Stacher, Philipp Stiegler, Jörg Lindenmann, Andrea Olschewski, Horst Olschewski, Andelko Hrzenjak Lung cancer is the leading cause of cancer deaths worldwide; survival times are poor despite therapy. The role of the two-pore domain K+ (K2P) channel TASK-1 (KCNK3) in lung cancer is at present unknown. We found that TASK-1 is expressed in non-small cell lung cancer (NSCLC) cell lines at variable levels. In a highly TASK-1 expressing NSCLC cell line, A549, a characteristic pH- and hypoxia-sensitive non-inactivating K+ current w...
Source: PLoS One - June 12, 2016 Category: Biomedical Science Authors: Katharina Leithner Source Type: research