• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

LSC Abstract - Toll-like receptor 10: Expression and functional role in LPS mediated inflammation
We examined TLR10 expression in normal and inflamed lungs from chickens and humans. Immunohistochemistry showed TLR10 in vascular endothelium in human and chicken lungs. Immunohistochemistry and Western blots showed an increase in TLR10 protein in lungs of chicken infected with E. coli or Fowl Adenovirus. Human neutrophils challenged with E. coli lipopolysaccharide (LPS) showed decreased total TLR10 protein and surface expression in 90 minutes. Confocal microscopy showed cytosolic and nuclear distribution of TLR10 in normal neutrophils. In the LPS-activated neutrophils, TLR10 colocalized with flotallin-1, a lipid raft mark...
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Balachandran, Y., Singh, B. Tags: 3.1 Molecular Pathology and Functional Genomics Source Type: research