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Source: European Respiratory Journal
Condition: Obstructive Sleep Apnea
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Total 2 results found since Jan 2013.
Increased CTGF expression of circulating fibrocytes in asthmatic patients with severe OSA - the role of HIF-1a and HDAC7
Conclusion: Severe OSA related hypoxia increases CTGF expression in circulating fibrocytes via activation of HIF-1α that requires HDAC7 nuclear co-transprotation. HDAC7 may serve a therapeutic target for airway remodeling in asthmatics with severe OSA.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Wang, T.-Y., Lo, Y.-L., Wang, C.-H., Kuo, H.-P. Tags: Airway Cell Biology and Immunopathology Source Type: research
The role of hypoxia and the circadian rhythm in sleep apnoea
Conclusion: Hypoxia in OSA causes an increase of HIF-1α which in turn disrupts the circadian rhythm in vitro. This pathway might be a potential target in tackling sleep apnoea.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Jaspers, T., Morrell, M., Simonds, A., Adcock, I., Durham, A. Tags: 4.2 Sleep and Control of Breathing Source Type: research
