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Source: Redox Biology
Cancer: Breast Cancer
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Expression of xCT and activity of system xc− are regulated by NRF2 in human breast cancer cells in response to oxidative stress
Publication date: Available online 18 March 2015 Source:Redox Biology Author(s): Eric Habib , Katja Linher-Melville , Han-Xin Lin , Gurmit Singh Cancer cells adapt to high levels of oxidative stress in order to survive and proliferate by activating key transcription factors. One such master regulator, the redox sensitive transcription factor NF E2 Related Factor 2 (NRF2), controls the expression of cellular defense genes including those encoding intracellular redox-balancing proteins involved in glutathione (GSH) synthesis. Under basal conditions, Kelch-like ECH-associated protein 1 (KEAP1) targets NRF2 for ubiquitinatio...
Source: Redox Biology - March 18, 2015 Category: Biology Source Type: research
