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Macrophage migration inhibitory factor is a novel prognostic marker for human oral squamous cell carcinoma
The objective of this study was to investigate the expression of MIF and its receptor CD74 in OSCC tissues, and to study the function of MIF in OSCC cells. Tissues of 90 patients with OSCC from the School of Stomatology, China Medical University were collected, and immunohistochemical staining and quantitative reverse transcription polymerase chain reaction were performed for MIF and CD74. The possible correlations between MIF and CD74 and clinical characteristics were analysed. The Kaplan-Meier analysis was used to determine the survival rates of patients. In addition, the proliferation and invasion of OSCC cells were eva...
Source: Pathology Research and Practice - July 10, 2018 Category: Pathology Source Type: research

Overexpression of KIFC1 and its association with spheroid formation in esophageal squamous cell carcinoma
Publication date: Available online 12 September 2017 Source:Pathology - Research and Practice Author(s): Takeharu Imai, Naohide Oue, Yuji Yamamoto, Ryuichi Asai, Naohiro Uraoka, Kazuhiro Sentani, Kazuhiro Yoshida, Wataru Yasui Esophageal squamous cell carcinoma (ESCC) is one of the most common human cancers. We previously reported that KIFC1 is involved in gastric cancer pathogenesis and that KIFC1 plays an important role in gastric cancer spheroid colony formation. However, the significance of KIFC1 in ESCC has not been examined. In the present study, we analyzed the expression and distribution of KIFC1 in 132 ESCC cases...
Source: Pathology Research and Practice - September 13, 2017 Category: Pathology Source Type: research