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Site-specific intestinal DMT1 silencing to mitigate iron absorption using pH-sensitive multi-compartmental nanoparticulate oral delivery system
We report a novel pH-sensitive multi-compartmental nanoparticulate (MCP) oral delivery system that encapsulates siRNA for silencing the divalent metal transporter 1 (DMT1) gene, a primary iron transporter highly expressed in the intestine. The gelatin nanoparticles-coated with Eudragit® L100–55 are able to protect siRNA from intracellular degradation and allow for sustained release of siRNA in the cytosol. When orally-administered, Eudragit® L100–55 based MCPs containing DMT1 siRNA/gelatin NPs specifically and significantly decreased the expression of DMT1 mRNA in the duodenum, which consequently decreased intestinal...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - October 16, 2019 Category: Nanotechnology Source Type: research

High-content analysis for mitophagy response to nanoparticles: A potential sensitive biomarker for nanosafety assessment
Publication date: Available online 20 September 2018Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Chengyong He, Shengwei Jiang, Huan Yao, Liyin Zhang, Chuanli Yang, Shan Jiang, Fengkai Ruan, Denglin Zhan, Gang Liu, Zhongning Lin, Yuchun Lin, Xiaoyuan ChenAbstractMitophagy, a selective autophagy of mitochondria, clears up damaged mitochondria to maintain cell homeostasis. We performed high-content analysis (HCA) to detect the increase of PINK1, an essential protein controlling mitophagy, in hepatic cells treated with several nanoparticles (NPs). PINK1 immunofluorescence-based HCA was more sensitive th...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - September 21, 2018 Category: Nanotechnology Source Type: research

Theranostic poly(lactic-co-glycolic acid) nanoparticle for magnetic resonance/infrared fluorescence bimodal imaging and efficient siRNA delivery to macrophages and its evaluation in a kidney injury model
Publication date: Available online 24 August 2017 Source:Nanomedicine: Nanotechnology, Biology and Medicine Author(s): Chuanxu Yang, Hieu Vu-Quang, Dina Michelle Unnerup Husum, Stine Julie Tingskov, Mads Sloth Vinding, Thomas Nielsen, Ping Song, Niels Chr. Nielsen, Rikke Nørregaard, Jørgen Kjems In this work, a theranostic nanoparticle was developed for multimodal imaging and siRNA delivery. The core of the nanoparticles (NP) was formed by encapsulation of superparamagnetic iron oxides and indocyanine green in a PLGA matrix to serve as a multimodal probe for near-infrared (NIFR) and magnetic resonance (MR) imaging. The ...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - August 24, 2017 Category: Nanotechnology Source Type: research