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Source: Nanomedicine: Nanotechnology, Biology and Medicine
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A nano-enabled cancer-specific ITCH RNAi chemotherapy booster for pancreatic cancer
Publication date: Available online 6 October 2014 Source:Nanomedicine: Nanotechnology, Biology and Medicine Author(s): Maria de la Fuente , Marie-Christine Jones , Manuel J. Santander-Ortega , Anja Mirenska , Preethi Marimuthu , Ijeoma Uchegbu , Andreas Schätzlein Gemcitabine is currently the standard therapy for pancreatic cancer. However, growing concerns over gemcitabine resistance mean that new combinatory therapies are required to prevent loss of efficacy with prolonged treatment. Here, we suggest that this could be achieved through co-administration of RNA interference agents targeting the ubiquitin ligase ITCH. S...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - November 4, 2014 Category: Nanotechnology Source Type: research
