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Nanoparticle-mediated knockdown of DNA repair sensitizes cells to radiotherapy and extends survival in a genetic mouse model of glioblastoma
Publication date: Available online 11 June 2017 Source:Nanomedicine: Nanotechnology, Biology and Medicine Author(s): Forrest M. Kievit, Kui Wang, Tatsuya Ozawa, Aria W. Tarudji, John R. Silber, Eric C. Holland, Richard G. Ellenbogen, Miqin Zhang Glioblastoma (GBM) remains incurable, and recurrent tumors that rarely respond to standard-of-care radiation and chemo therapies. Therefore, strategies that enhance the effects of these therapies should provide significant benefits to GBM patients. We have developed a nanoparticle delivery vehicle that can stably bind and protect nucleic acids for specific delivery into brain tumo...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - June 11, 2017 Category: Nanotechnology Source Type: research

Intranasal Brain Delivery of Cationic Nanoemulsion-Encapsulated TNFα siRNA in Prevention of Experimental Neuroinflammation
Publication date: Available online 6 January 2016 Source:Nanomedicine: Nanotechnology, Biology and Medicine Author(s): Sunita Yadav, Srujan K. Gandham, Riccardo Panicucci, Mansoor M. Amiji Neuroinflammation is a hallmark of acute and chronic neurodegenerative disorders. Activated microglia and secreted factors such as tumor necrosis factor-alpha (TNFα) are key mediators of neuroinflammation and may contribute to neuronal dysfunction. The main aim of this study was to evaluate the therapeutic efficacy of intranasal cationic nanoemulsions encapsulating an anti-TNFα siRNA, for potential anti-inflammatory therapy, test...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - January 12, 2016 Category: Nanotechnology Source Type: research