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Source: Molecular and Cellular Endocrinology
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Total 76 results found since Jan 2013.
X-linked lymphocyte regulated gene 5c-like (Xlr5c-like) is a novel target of progesterone action in granulosa cells of periovulatory rat ovaries
In conclusion, this is the first report showing the spatiotemporally regulated expression of Xlr5c-like mRNA by hCG in rat periovulatory ovaries. P4/PGR mediates the LH-induced increase in Xlr5c-like mRNA. In turn, Xlr5c-like is involved in regulating the expression of specific ovulatory genes such as Snap25, Cxcr4, and Adamts1, possibly acting in the nucleus of periovulatory granulosa cells.
Source: Molecular and Cellular Endocrinology - July 24, 2015 Category: Endocrinology Source Type: research
Preadipocyte proliferation is elevated by calcium sensing receptor activation
This study evaluated whether CaSR activation elevates preadipocyte proliferation. Human LS14 preadipocytes were exposed to CaSR activators cinacalcet (2 µM), GdCl3 (5 µM) and spermine (1 µM), and cell viability was evaluated after 72h. CaSR activators elevated proliferation by 19–24%, and CaSR silencing (siRNA) abolished the effect. Cinacalcet elevated phospho-ERK1/2 content, and upstream inhibition of ERK1/2 phosphorylation reverted cinacalcet-induced proliferation. Cinacalcet also elevated expression of the proinflammatory factors IL1β, IL6 and CCL2. The results suggest that CaSR induces preadipocyte prolifer...
Source: Molecular and Cellular Endocrinology - July 24, 2015 Category: Endocrinology Source Type: research
Dihydromyricetin stimulates irisin secretion partially via the PGC-1α pathway
Publication date: 5 September 2015 Source:Molecular and Cellular Endocrinology, Volume 412 Author(s): Qicheng Zhou, Ka Chen, Peng Liu, Yanxiang Gao, Dan Zou, Huiling Deng, Yujie Huang, Qianyong Zhang, Jundong Zhu, Mantian Mi Irisin, derived from FNDC5, is an exercise-induced myokine that can stimulate the ‘browning’ of white adipose tissue, which is regulated by peroxisome proliferator-activated receptor γ coactivator 1 α (PGC-1α). Dihydromyricetin (DHM), a natural flavonoid, exerts its activities through PGC-1α activation. Here, we explored whether DHM could mimic the effects of exercise on irisin secr...
Source: Molecular and Cellular Endocrinology - July 24, 2015 Category: Endocrinology Source Type: research
AMP-activated protein kinase suppresses the expression of LXR/SREBP-1 signaling-induced ANGPTL8 in HepG2 cells
Publication date: 15 October 2015 Source:Molecular and Cellular Endocrinology, Volume 414 Author(s): Jinmi Lee, Seok-Woo Hong, Se Eun Park, Eun-Jung Rhee, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Won-Young Lee ANGPTL8 is a liver-derived secretory protein that leads to elevated serum triglyceride and the level of circulating ANGPTL8 is strongly associated with obesity and diabetes. Here we investigated the mechanisms of activation and inhibition of ANGPTL8 expression in hepatocytes. The expression of ANGPTL8 was significantly increased in HepG2 cells exposed to palmitic acid, tunicamycin, or T0901317, and was r...
Source: Molecular and Cellular Endocrinology - August 8, 2015 Category: Endocrinology Source Type: research
Ghrelin regulates GLP-1 production through mTOR signaling in L cells
Publication date: 15 November 2015 Source:Molecular and Cellular Endocrinology, Volume 416 Author(s): Geyang Xu, Xiaosi Hong, Hong Tang, Sushi Jiang, Fenting Liu, Zhemin Shen, Ziru Li, Weizhen Zhang Glucagon-like peptide (GLP-1), an intestinal incretin produced in L-cells and released in response to meal intake, functions to promote insulin secretion and to decrease plasma glucose. Ghrelin is an orexigenic hormone critical for glucose homeostasis. The molecular mechanism by which ghrelin alters GLP-1 production remains largely unknown. Here we showed that ghrelin attenuates GLP-1 production through mTOR signaling...
Source: Molecular and Cellular Endocrinology - October 14, 2015 Category: Endocrinology Source Type: research
C1q/TNF-related protein-9 inhibits cytokine-induced vascular inflammation and leukocyte adhesiveness via AMP-activated protein kinase activation in endothelial cells
Publication date: Available online 31 October 2015 Source:Molecular and Cellular Endocrinology Author(s): Chang Hee Jung, Min Jung Lee, Yu Mi Kang, Yoo La Lee, So Mi Seol, Hae Kyeong Yoon, Sang-Wook Kang, Woo Je Lee, Joong-Yeol Park Although recent studies have reported cardioprotective effects of C1q/TNF-related protein 9 (CTRP9), the closet adiponectin paralog, its role on cytokine-induced endothelial inflammation is unknown. We investigated whether CTRP9 prevented inflammatory cytokine-induced nuclear factor-kappa B (NF-κB) activation and inhibited the expression of adhesion molecules and a chemokine in the ...
Source: Molecular and Cellular Endocrinology - October 31, 2015 Category: Endocrinology Source Type: research
Estrogen suppresses breast cancer proliferation through GPER / p38 MAPK axis during hypoxia
In conclusion, Estrogen suppresses breast cancer growth by inhibiting G1/S phase transition through GPER/ROS/p38 MAPK/p21 mediated signaling during hypoxic condition.
Source: Molecular and Cellular Endocrinology - November 6, 2015 Category: Endocrinology Source Type: research
TRAF2 mediates JNK and STAT3 activation in response to IL-1β and IFNγ and facilitates apoptotic death of insulin-producing β-cells
Publication date: Available online 22 November 2015 Source:Molecular and Cellular Endocrinology Author(s): Michala Cecilie Prause, Lukas Adrian Berchtold, Adriana Ibarra Urizar, Anne Mette Hyldgaard Trauelsen, Nils Billestrup, Thomas Mandrup-Poulsen, Joachim Størling Interleukin-1β (IL-1β) and interferon-γ (IFNγ) contribute to type 1 diabetes (T1D) by inducing β-cell death. Tumor necrosis factor (TNF) receptor-associated factor (TRAF) proteins are adaptors that transduce signaling from a variety of membrane receptors including cytokine receptors. We show here that IL-1β and IFNγ upregulate the expression o...
Source: Molecular and Cellular Endocrinology - November 23, 2015 Category: Endocrinology Source Type: research
Increased IGFBP-1 phosphorylation in response to leucine deprivation is mediated by CK2 and PKC
Publication date: Available online 28 December 2015 Source:Molecular and Cellular Endocrinology Author(s): Niyati Malkani, Kyle Biggar, Majida Abu Shehab, Shawn Li, Thomas Jansson, Madhulika B. Gupta Insulin-like growth factor binding protein-1 (IGFBP-1), secreted by fetal liver, is a key regulator of IGF-I bioavailability and fetal growth. IGFBP-1 phosphorylation decreases IGF-I bioavailability and diminishes its growth-promoting effects. Growth-restricted fetuses have decreased levels of circulating essential amino acids. We recently showed that IGFBP-1 hyperphosphorylation (pSer101/119/169) in response to leucin...
Source: Molecular and Cellular Endocrinology - December 28, 2015 Category: Endocrinology Source Type: research
Endoglin (CD105) coordinates the process of endometrial receptivity for embryo implantation
In conclusion, our findings reveal the association of endoglin with endometrial receptivity, which is important for embryo attachment.
Source: Molecular and Cellular Endocrinology - January 21, 2016 Category: Endocrinology Source Type: research
HNF1 regulates critical processes in the human epididymis epithelium
Publication date: Available online 22 January 2016 Source:Molecular and Cellular Endocrinology Author(s): James A. Browne, Rui Yang, Scott E. Eggener, Shih-Hsing Leir, Ann Harris The luminal environment of the epididymis participates in sperm maturation and impacts male fertility. It is dependent on the coordinated expression of many genes encoding proteins with a role in epithelial transport. We identified cis-regulatory elements for critical genes in epididymis function, by mapping open chromatin genome-wide in human epididymis epithelial (HEE) cells. Bioinformatic predictions of transcription factors binding to t...
Source: Molecular and Cellular Endocrinology - January 23, 2016 Category: Endocrinology Source Type: research
Endoplasmic reticulum stress regulates inflammation and insulin resistance in pregnant skeletal muscle
Publication date: Available online 20 February 2016 Source:Molecular and Cellular Endocrinology Author(s): Stella Liong, Martha Lappas Sterile inflammation and infection are key mediators of inflammation and peripheral insulin resistance associated with gestational diabetes mellitus (GDM). Studies have shown endoplasmic reticulum (ER) stress to induce inflammation and insulin resistance associated with obesity and type 2 diabetes, however is paucity of studies investigating the effects of ER stress in skeletal muscle on inflammation and insulin resistance associated with GDM. ER stress proteins IRE1α, GRP78 and XBP-1s...
Source: Molecular and Cellular Endocrinology - February 20, 2016 Category: Endocrinology Source Type: research
Endoplasmic reticulum stress regulates inflammation and insulin resistance in skeletal muscle from pregnant women
Publication date: 15 April 2016 Source:Molecular and Cellular Endocrinology, Volume 425 Author(s): Stella Liong, Martha Lappas Sterile inflammation and infection are key mediators of inflammation and peripheral insulin resistance associated with gestational diabetes mellitus (GDM). Studies have shown endoplasmic reticulum (ER) stress to induce inflammation and insulin resistance associated with obesity and type 2 diabetes, however is paucity of studies investigating the effects of ER stress in skeletal muscle on inflammation and insulin resistance associated with GDM. ER stress proteins IRE1α, GRP78 and XBP-1s were up...
Source: Molecular and Cellular Endocrinology - March 3, 2016 Category: Endocrinology Source Type: research
Triiodothyronine enhances accumulation of intracellular lipids in adipocytes through thyroid hormone receptor α via direct and indirect mechanisms
Publication date: Available online 28 April 2016 Source:Molecular and Cellular Endocrinology Author(s): Yurina Gambo, Miki Matsumura, Ko Fujimori Triiodothyronine (T3) enhanced the expression of adipogenic and lipogenic genes with elevation of the intracellular lipids through thyroid hormone receptor (TR) α in mouse 3T3-L1 cells. However, the transcription of the SREBP-1c and HSL genes was decreased by T3. Such T3-mediated alterations were negated by TRα siRNA. Chromatin immunoprecipitation assay showed that the binding of TRα to the TR-responsive element (TRE) of the FAS promoter was elevated by T3. In contrast, t...
Source: Molecular and Cellular Endocrinology - April 28, 2016 Category: Endocrinology Source Type: research
Sensitization of androgen refractory prostate cancer cells to anti-androgens through re-expression of epigenetically repressed androgen receptor – Synergistic action of quercetin and curcumin
Publication date: Available online 28 April 2016 Source:Molecular and Cellular Endocrinology Author(s): Vikas Sharma, Lokesh Kumar, Sujit K. Mohanty, Jagdamba P. Maikhuri, Singh Rajender, Gopal Gupta Epigenetic repression of Androgen Receptor (AR) gene by hypermethylation of its promoter causes resistance in prostate cancer (CaP) to androgen deprivation therapy with anti-androgens. Some dietary phytocompounds like quercetin (Q) and curcumin (C) with reported DNMT-inhibitory activity were tested for their ability to re-express the AR in AR-negative CaP cell lines PC3 and DU145. Combined treatment with Q+C was much m...
Source: Molecular and Cellular Endocrinology - April 28, 2016 Category: Endocrinology Source Type: research
