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Participation of NADPH 4 oxidase in thyroid regulation
Publication date: Available online 11 October 2018Source: Molecular and Cellular EndocrinologyAuthor(s): Romina Oglio, Leonardo Salvarredi, Luciano Rossich, Silvia Copelli, Mario Pisarev, Guillermo Juvenal, Lisa ThomaszAbstractDifferent factors are involved in thyroid function and proliferation such as thyrotropin (TSH), insulin, growth factors, iodide, etc. TSH and IGF1/insulin increase proliferation rate and stimulate genes involved in thyroid differentiation. In the present study, we analyse the physiological regulation of NOX4 expression by TSH, insulin and iodine, and the role of NOX4 on thyroid genes expression. Diff...
Source: Molecular and Cellular Endocrinology - October 12, 2018 Category: Endocrinology Source Type: research

Regulation of NADPH oxidase NOX4 by delta iodolactone (IL- δ) in thyroid cancer cells
Conclusions The antiproliferative and pro-apoptotic effect of IL-δ is mediated by different mechanisms and pathway involving different sources of ROS generation depending on the cellular context. Graphical abstract
Source: Molecular and Cellular Endocrinology - May 27, 2018 Category: Endocrinology Source Type: research