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Total 16 results found since Jan 2013.

Excessive iodine induces thyroid follicular epithelial cells apoptosis by activating HIF-1 α-mediated hypoxia pathway in Hashimoto thyroiditis
CONCLUSION: Our study confirmed that excessive iodine adsorption activates the HIF-1α-mediated hypoxia pathway to promote apoptosis of TFCs, which may be an important risk factor contributing to HT development.PMID:36807042 | DOI:10.1007/s11033-023-08273-z
Source: Mol Biol Cell - February 22, 2023 Category: Molecular Biology Authors: Lili Zhang Xiaojing Sun Lin Liu Ping Wang Linxue Qian Source Type: research

Downregulation of Rap1GAP Expression Activates the TGF- < em > β < /em > /Smad3 Pathway to Inhibit the Expression of Sodium/Iodine Transporter in Papillary Thyroid Carcinoma Cells
CONCLUSION: The downregulation of Rap1GAP expression can activate the TGF-β/Smad3 pathway to inhibit NIS expression and alter the tumor cell functions of PTC.PMID:34840979 | PMC:PMC8616680 | DOI:10.1155/2021/6840642
Source: Biomed Res - November 29, 2021 Category: Research Authors: Zheng Yan Wang Yangyanqiu Han Shuwen Mao Jing Liao Haihong Chen Gong Jin Yin Zhou Qing Gao Weili Source Type: research

Stromal interaction molecule 1 (STIM1) knock down attenuates invasion and proliferation and enhances the expression of thyroid-specific proteins in human follicular thyroid cancer cells
Cell Mol Life Sci. 2021 Jun 21. doi: 10.1007/s00018-021-03880-0. Online ahead of print.ABSTRACTStromal interaction molecule 1 (STIM1) and the ORAI1 calcium channel mediate store-operated calcium entry (SOCE) and regulate a multitude of cellular functions. The identity and function of these proteins in thyroid cancer remain elusive. We show that STIM1 and ORAI1 expression is elevated in thyroid cancer cell lines, compared to primary thyroid cells. Knock-down of STIM1 or ORAI1 attenuated SOCE, reduced invasion, and the expression of promigratory sphingosine 1-phosphate and vascular endothelial growth factor-2 receptors in th...
Source: Cellular and Molecular Life Sciences : CMLS - June 22, 2021 Category: Cytology Authors: Muhammad Yasir Asghar Taru Lassila Ilkka Paatero Van Dien Nguyen Pauliina Kronqvist Jixi Zhang Anna Slita Christoffer L öf You Zhou Jessica Rosenholm Kid T örnquist Source Type: research

APX-115A, a pan-NADPH oxidase inhibitor, induces caspase-dependent cell death by suppressing NOX4-ROS signaling in EBV-infected retinal epithelial cells.
Conclusion Taken together, these our results suggest that APX-115A could be a therapeutic agent for treating EBV-infected retinal cells or diseases by inhibiting LMP1-NOX4-ROS signaling. PMID: 31951764 [PubMed - as supplied by publisher]
Source: Current Eye Research - January 16, 2020 Category: Opthalmology Authors: Hong SW, Noh MH, Kim YS, Jin DH, Moon SH, Yang JW, Hur DY Tags: Curr Eye Res Source Type: research

Scutellarin Protects Against Myocardial Ischemia-Reperfusion Injury by Suppressing NLRP3 Inflammasome Activation
ConclusionsThe cardioprotective effect of Scu was achieved through its anti-inflammatory effect. It suppressed the activation of NLRP3 inflammasome. In addition, inflammasome restriction by Scu was dependent on Akt activation and mTORC1 inhibition.
Source: Phytomedicine - January 16, 2020 Category: Drugs & Pharmacology Source Type: research

Systems Biology Approaches and Precision Oral Health: A Circadian Clock Perspective
Conclusion Most head and neck pathologies show a broad cellular heterogeneity making it difficult to achieve an accurate diagnosis and efficient treatment (Graf and Zavodszky, 2017; Lo Nigro et al., 2017). Single cell analysis of circadian omics (Lande-Diner et al., 2015; Abraham et al., 2018), may be a crucial tool needed in the future to fully understand the circadian control of head and neck diseases. It becomes more obvious that there is only a small genetic component but a largely unknown epigenetics and/or environmental component for most of the head and neck pathologies (Moosavi and Motevalizadeh Ardekani, 2016; He...
Source: Frontiers in Physiology - April 15, 2019 Category: Physiology Source Type: research

Targeting XIAP Via Degradation of MDM-2 By MX69 in Aggressive Lymphomas
Conclusion: Our data suggests that in vitro exposure of a wide variety of B-cell lymphoma cell lines (including BL, DLBCL, MCL or RRCL) to MX69 resulted in anti-tumor activity. Perhaps related to its anti-tumor effects, MX69 inhibited XIAP levels. These findings are similar to prior SiRNA XIAP knockdown experiments. Strong synergistic activity was observed when XIAP was combined with various chemotherapy agents and small molecules inhibitors (such as Venetoclax, ixazomib or ibrutinib). Ex vivo experiments using primary tumor cells isolated from lymphoma patients and lymphoma mouse models are been planned. Targeting Mdm2 an...
Source: Blood - November 21, 2018 Category: Hematology Authors: Khan, S., Runckel, K., Mavis, C., Barth, M. J., Hernandez-Ilizaliturri, F. J. Tags: 625. Lymphoma: Pre-Clinical-Chemotherapy and Biologic Agents Source Type: research

Participation of NADPH 4 oxidase in thyroid regulation
Publication date: Available online 11 October 2018Source: Molecular and Cellular EndocrinologyAuthor(s): Romina Oglio, Leonardo Salvarredi, Luciano Rossich, Silvia Copelli, Mario Pisarev, Guillermo Juvenal, Lisa ThomaszAbstractDifferent factors are involved in thyroid function and proliferation such as thyrotropin (TSH), insulin, growth factors, iodide, etc. TSH and IGF1/insulin increase proliferation rate and stimulate genes involved in thyroid differentiation. In the present study, we analyse the physiological regulation of NOX4 expression by TSH, insulin and iodine, and the role of NOX4 on thyroid genes expression. Diff...
Source: Molecular and Cellular Endocrinology - October 12, 2018 Category: Endocrinology Source Type: research

Regulation of NADPH oxidase NOX4 by delta iodolactone (IL- δ) in thyroid cancer cells
Conclusions The antiproliferative and pro-apoptotic effect of IL-δ is mediated by different mechanisms and pathway involving different sources of ROS generation depending on the cellular context. Graphical abstract
Source: Molecular and Cellular Endocrinology - May 27, 2018 Category: Endocrinology Source Type: research