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Rosiglitazone inhibition of calvaria-derived osteoblast differentiation is through both of PPARγ and GPR40 and GSK3β-dependent pathway
This study aims to investigate the effects of RSG on differentiation and mineralization of osteoblasts using primary cultured mouse fetal calvaria-derived osteoblasts as a model, and elucidate the receptor and signaling pathways responsible for these effects. We found that RSG suppressed the differentiation and mineralization of calvaria-derived osteoblasts. Peroxisome proliferators-activated receptor γ (PPARγ) siRNA significantly reversed the inhibitory effect of RSG on osteogenic differentiation. The expression of G protein-coupled receptor (GPR) 40 was suppressed during differentiation, but was increased by RSG treatm...
Source: Molecular and Cellular Endocrinology - July 31, 2015 Category: Endocrinology Source Type: research

Involvement of insulin-like growth factor binding protein-3 in peroxisome proliferator-activated receptor gamma-mediated inhibition of breast cancer cell growth
Publication date: 5 January 2015 Source:Molecular and Cellular Endocrinology, Volume 399 Author(s): Cindy K. Pon , Sue M. Firth , Robert C. Baxter We have previously reported that insulin-like growth factor binding protein-3 (IGFBP-3), a protein with dichotomous effects on both cell proliferation and cell survival, interacts with peroxisome proliferator-activated receptor gamma (PPARγ) and inhibits adipogenic PPARγ signaling. We now show that IGFBP-3 and PPARγ interact in breast cancer cells, through amino- and carboxyl-terminal residues of IGFBP-3. IGFBP-3 and the PPARγ ligands, rosiglitazone or 15-deoxy-Δ12,14-pro...
Source: Molecular and Cellular Endocrinology - November 13, 2014 Category: Endocrinology Source Type: research

Involvement of insulin-like growth factor binding protein-3 in peroxisome proliferator activated receptor gamma-mediated inhibition of breast cancer cell growth
Publication date: Available online 31 October 2014 Source:Molecular and Cellular Endocrinology Author(s): Cindy K. Pon , Sue M. Firth , Robert C. Baxter We have previously reported that insulin-like growth factor binding protein-3 (IGFBP-3), a protein with dichotomous effects on both cell proliferation and cell survival, interacts with peroxisome proliferator-activated receptor gamma (PPARγ) and inhibits adipogenic PPARγ signaling. We now show that IGFBP-3 and PPARγ interact in breast cancer cells, through amino- and carboxyl-terminal residues of IGFBP-3. IGFBP-3 and the PPARγ ligands, rosiglitazone or 15-deoxy-Δ12,...
Source: Molecular and Cellular Endocrinology - November 3, 2014 Category: Endocrinology Source Type: research