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Involvement of CREB-regulated transcription coactivators (CRTC) in transcriptional activation of steroidogenic acute regulatory protein (Star) by ACTH
Publication date: Available online 8 October 2019Source: Molecular and Cellular EndocrinologyAuthor(s): Lorna I.F. Smith, Victoria Huang, Mark Olah, Loc Trinh, Ying Liu, Georgina Hazell, Becky Conway-Campbell, Zidong Zhao, Antoine Martinez, Anne-Marie Lefrançois-Martinez, Stafford Lightman, Francesca Spiga, Greti AguileraAbstractStudies in vivo have suggested the involvement of CREB-regulated transcription coactivator (CRTC)2 on ACTH-induced transcription of the key steroidogenic protein, Steroidogenic Acute Regulatory (StAR). The present study uses two ACTH-responsive adrenocortical cell-lines, to examine the role of CRT...
Source: Molecular and Cellular Endocrinology - October 9, 2019 Category: Endocrinology Source Type: research

Molecular mechanisms underlying oxytocin-induced cardiomyocyte protection from simulated ischemia–reperfusion
In conclusion, the OTR protected H9c2 cells against I–R, especially if activated at the onset of ischemia or reperfusion. The OTR-transduced signals include pro-survival kinases, such as Akt and PKG.
Source: Molecular and Cellular Endocrinology - July 24, 2015 Category: Endocrinology Source Type: research

Transmembrane tumor necrosis factor-alpha sensitizes adipocytes to insulin
Publication date: 5 May 2015 Source:Molecular and Cellular Endocrinology, Volume 406 Author(s): Wenjing Zhou , Peng Yang , Li Liu , Shan Zheng , Qingling Zeng , Huifang Liang , Yazhen Zhu , Zunyue Zhang , Jing Wang , Bingjiao Yin , Feili Gong , Yiping Wu , Zhuoya Li Transmembrane TNF-α (tmTNF-α) acts both as a ligand, delivering ‘forward signaling’ via TNFR, and as a receptor, transducing ‘reverse signaling’. The contradiction of available data regarding the effect of tmTNF-α on insulin resistance may be due to imbalance in both signals. Here, we demonstrated that high glucose-induced impairment of insulin-sti...
Source: Molecular and Cellular Endocrinology - March 10, 2015 Category: Endocrinology Source Type: research

Oxytocin activates NF-κB-mediated inflammatory pathways in human gestational tissues
Publication date: Available online 14 November 2014 Source:Molecular and Cellular Endocrinology Author(s): Sung Hye Kim , David A. MacIntyre , Maria Firmino Da Silva , Andrew M. Blanks , Yun S Lee , Steven Thornton , Phillip R. Bennett , Vasso Terzidou Human labor, both at term and preterm, is preceded by NF-κB-mediated inflammatory activation within the uterus leading to myometrial activation, fetal membrane remodelling and cervical ripening. The stimuli triggering inflammatory activation in normal human parturition are not fully understood. We show that the neurohypophyseal peptide, oxytocin (OT), activates NF-κB and...
Source: Molecular and Cellular Endocrinology - November 14, 2014 Category: Endocrinology Source Type: research