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Source: Molecular and Cellular Endocrinology
Condition: Obesity
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Total 11 results found since Jan 2013.
Calcium sensing receptor activation in THP-1 macrophages triggers NLRP3 inflammasome and human preadipose cell inflammation
Publication date: Available online 15 November 2019Source: Molecular and Cellular EndocrinologyAuthor(s): Amanda D'Espessailles, Natalia Santillana, Sofía Sanhueza, Cecilia Fuentes, Mariana CifuentesAbstractExcess adipose tissue (AT) associates with inflammation and obesity-related diseases. We studied whether calcium-sensing receptor (CaSR)-mediated NLRP3 inflammasome activation in THP-1 macrophages elevates inflammation in LS14 preadipocytes, modeling deleterious AT cell crosstalk. THP-1 macrophages exposed to Cinacalcet (CaSR activator, 2 μM, 4 h) showed elevated proinflammatory marker and NLRP3 inflammasome mRNA,...
Source: Molecular and Cellular Endocrinology - November 15, 2019 Category: Endocrinology Source Type: research
Asprosin impairs insulin secretion in response to glucose and viability through TLR4/JNK-mediated inflammation
This report suggests asprosin as a novel therapeutic target for the treatment of type 2 diabetes through preservation of β-cell function.Graphical abstract
Source: Molecular and Cellular Endocrinology - March 8, 2019 Category: Endocrinology Source Type: research
Novel ABCA1 peptide agonists with antidiabetic action
Publication date: Available online 2 October 2018Source: Molecular and Cellular EndocrinologyAuthor(s): Salman Azhar, Stefanie Bittner, Jie Hu, Wen-Jun Shen, Yuan Cortez, Xiao Hao, Han Lu, Jens O. Lagerstedt, Fredric B. Kraemer, Jan O. JohanssonAbstractPreviously, apoE-derived ABCA1 agonist peptides have been shown to possess anti-atherosclerotic and possibly antidiabetic properties. Here we assessed the in vitro and in vivo actions of a second generation of ABCA1 peptide agonists, CS6253 and T6991-2, on glucose homeostasis. The results show that these two peptides improve glucose tolerance in a prediabetic diet-induced ob...
Source: Molecular and Cellular Endocrinology - October 5, 2018 Category: Endocrinology Source Type: research
Hyperlipidemia-induced hepassocin in the liver contributes to insulin resistance in skeletal muscle
In conclusion, we elucidated that ER stress induced by palmitate could increase the expression of HPS in hepatocytes and further contribute to the development of insulin resistance in skeletal muscle via EGFR/JNK-mediated pathway. Taken together, we suggest that HPS could be a therapeutic target for obesity-linked insulin resistance. Graphical abstract
Source: Molecular and Cellular Endocrinology - October 28, 2017 Category: Endocrinology Source Type: research
Annexin A6 regulates adipocyte lipid storage and adiponectin release
Publication date: 5 January 2017 Source:Molecular and Cellular Endocrinology, Volume 439 Author(s): Sabrina Krautbauer, Elisabeth M. Haberl, Kristina Eisinger, Rebekka Pohl, Lisa Rein-Fischboeck, Carles Rentero, Anna Alvarez-Guaita, Carlos Enrich, Thomas Grewal, Christa Buechler, Markus Neumeier Lipid storage and adipokine secretion are critical features of adipocytes. Annexin A6 (AnxA6) is a lipid-binding protein regulating secretory pathways and its role in adiponectin release was examined. The siRNA-mediated AnxA6 knock-down in 3T3-L1 preadipocytes impaired proliferation, and differentiation of AnxA6-depleted cells to ...
Source: Molecular and Cellular Endocrinology - November 22, 2016 Category: Endocrinology Source Type: research
Exendin-4 decreases ghrelin levels through mTOR signaling
Publication date: 5 December 2016 Source:Molecular and Cellular Endocrinology, Volume 437 Author(s): Xiaosi Hong, Heng Zhang, Hongbin Liang, Danjie Li, Jiana Huang, Zhi Li, Sibo Jiang, Weizhen Zhang, Geyang Xu Exendin-4 (EX-4), a long-acting glucagon-like peptide-1 receptor (GLP-1R) agonist, regulates feeding behavior through its ability to inhibit gastric emptying. Ghrelin, a gastric hormone, provides a hunger signal to the central nervous system to stimulate appetite. Here, we report that EX-4 suppresses ghrelin production through the mTORC1-dependent mechanism. Central administration of EX-4 reduces gastric, hypothalam...
Source: Molecular and Cellular Endocrinology - August 30, 2016 Category: Endocrinology Source Type: research
Endoplasmic reticulum stress regulates inflammation and insulin resistance in skeletal muscle from pregnant women
Publication date: 15 April 2016 Source:Molecular and Cellular Endocrinology, Volume 425 Author(s): Stella Liong, Martha Lappas Sterile inflammation and infection are key mediators of inflammation and peripheral insulin resistance associated with gestational diabetes mellitus (GDM). Studies have shown endoplasmic reticulum (ER) stress to induce inflammation and insulin resistance associated with obesity and type 2 diabetes, however is paucity of studies investigating the effects of ER stress in skeletal muscle on inflammation and insulin resistance associated with GDM. ER stress proteins IRE1α, GRP78 and XBP-1s were up...
Source: Molecular and Cellular Endocrinology - March 3, 2016 Category: Endocrinology Source Type: research
Endoplasmic reticulum stress regulates inflammation and insulin resistance in pregnant skeletal muscle
Publication date: Available online 20 February 2016 Source:Molecular and Cellular Endocrinology Author(s): Stella Liong, Martha Lappas Sterile inflammation and infection are key mediators of inflammation and peripheral insulin resistance associated with gestational diabetes mellitus (GDM). Studies have shown endoplasmic reticulum (ER) stress to induce inflammation and insulin resistance associated with obesity and type 2 diabetes, however is paucity of studies investigating the effects of ER stress in skeletal muscle on inflammation and insulin resistance associated with GDM. ER stress proteins IRE1α, GRP78 and XBP-1s...
Source: Molecular and Cellular Endocrinology - February 20, 2016 Category: Endocrinology Source Type: research
AMP-activated protein kinase suppresses the expression of LXR/SREBP-1 signaling-induced ANGPTL8 in HepG2 cells
Publication date: 15 October 2015 Source:Molecular and Cellular Endocrinology, Volume 414 Author(s): Jinmi Lee, Seok-Woo Hong, Se Eun Park, Eun-Jung Rhee, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Won-Young Lee ANGPTL8 is a liver-derived secretory protein that leads to elevated serum triglyceride and the level of circulating ANGPTL8 is strongly associated with obesity and diabetes. Here we investigated the mechanisms of activation and inhibition of ANGPTL8 expression in hepatocytes. The expression of ANGPTL8 was significantly increased in HepG2 cells exposed to palmitic acid, tunicamycin, or T0901317, and was r...
Source: Molecular and Cellular Endocrinology - August 8, 2015 Category: Endocrinology Source Type: research
Preadipocyte proliferation is elevated by calcium sensing receptor activation
This study evaluated whether CaSR activation elevates preadipocyte proliferation. Human LS14 preadipocytes were exposed to CaSR activators cinacalcet (2 µM), GdCl3 (5 µM) and spermine (1 µM), and cell viability was evaluated after 72h. CaSR activators elevated proliferation by 19–24%, and CaSR silencing (siRNA) abolished the effect. Cinacalcet elevated phospho-ERK1/2 content, and upstream inhibition of ERK1/2 phosphorylation reverted cinacalcet-induced proliferation. Cinacalcet also elevated expression of the proinflammatory factors IL1β, IL6 and CCL2. The results suggest that CaSR induces preadipocyte prolifer...
Source: Molecular and Cellular Endocrinology - July 24, 2015 Category: Endocrinology Source Type: research
Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated skeletal muscle insulin resistance
Publication date: 5 August 2014 Source:Molecular and Cellular Endocrinology, Volume 393, Issues 1–2 Author(s): Nicola A. Talbot , Caroline P. Wheeler-Jones , Mark E. Cleasby Obesity and saturated fatty acid (SFA) treatment are both associated with skeletal muscle insulin resistance (IR) and increased macrophage infiltration. However, the relative effects of SFA and unsaturated fatty acid (UFA)-activated macrophages on muscle are unknown. Here, macrophages were treated with palmitic acid, palmitoleic acid or both and the effects of the conditioned medium (CM) on C2C12 myotubes investigated. CM from palmitic acid-treated...
Source: Molecular and Cellular Endocrinology - November 23, 2014 Category: Endocrinology Source Type: research
