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Pannexin-2-deficiency sensitizes pancreatic β-cells to cytokine-induced apoptosis in vitro and impairs glucose tolerance in vivo
Publication date: Available online 5 April 2017 Source:Molecular and Cellular Endocrinology Author(s): Lukas A. Berchtold, Michela Miani, Thi A. Diep, Andreas N. Madsen, Valentina Cigliola, Maikel Colli, Jelena M. Krivokapic, Flemming Pociot, Decio L. Eizirik, Paolo Meda, Birgitte Holst, Nils Billestrup, Joachim Størling Pannexins (Panx's) are membrane proteins involved in a variety of biological processes, including cell death signaling and immune functions. The role and functions of Panx's in pancreatic β-cells remain to be clarified. Here, we show Panx1 and Panx2 expression in isolated islets, primary β-cells, and Î...
Source: Molecular and Cellular Endocrinology - April 11, 2017 Category: Endocrinology Source Type: research

Pannexin-2-deficiency sensitizes pancreatic β-cells to cytokine-induced apoptosis in vitro and impairs glucose tolerance in vivo
Publication date: Available online 5 April 2017 Source:Molecular and Cellular Endocrinology Author(s): Lukas A. Berchtold, Michela Miani, Thi A. Diep, Andreas N. Madsen, Valentina Cigliola, Maikel Colli, Jelena M. Krivokapic, Flemming Pociot, Decio L. Eizirik, Paolo Meda, Birgitte Holst, Nils Billestrup, Joachim Størling Pannexins (Panx's) are membrane proteins involved in a variety of biological processes, including cell death signaling and immune functions. The role and functions of Panx's in pancreatic β-cells remain to be clarified. Here, we show Panx1 and Panx2 expression in isolated islets, primary β-cells, and Î...
Source: Molecular and Cellular Endocrinology - April 6, 2017 Category: Endocrinology Source Type: research

TRAF2 mediates JNK and STAT3 activation in response to IL-1β and IFNγ and facilitates apoptotic death of insulin-producing β-cells
Publication date: Available online 22 November 2015 Source:Molecular and Cellular Endocrinology Author(s): Michala Cecilie Prause, Lukas Adrian Berchtold, Adriana Ibarra Urizar, Anne Mette Hyldgaard Trauelsen, Nils Billestrup, Thomas Mandrup-Poulsen, Joachim Størling Interleukin-1β (IL-1β) and interferon-γ (IFNγ) contribute to type 1 diabetes (T1D) by inducing β-cell death. Tumor necrosis factor (TNF) receptor-associated factor (TRAF) proteins are adaptors that transduce signaling from a variety of membrane receptors including cytokine receptors. We show here that IL-1β and IFNγ upregulate the expression o...
Source: Molecular and Cellular Endocrinology - November 23, 2015 Category: Endocrinology Source Type: research