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Identification of retinoid acid induced 16 as a novel androgen receptor target in prostate cancer cells
ConclusionsWe demonstrate for the first time that RAI16 is a direct target gene of AR. RAI16 may involved in cell growth of prostate cancer cells in response to AR signaling.
Source: Molecular and Cellular Endocrinology - January 31, 2020 Category: Endocrinology Source Type: research

Sensitization of androgen refractory prostate cancer cells to anti-androgens through re-expression of epigenetically repressed androgen receptor – Synergistic action of quercetin and curcumin
Publication date: Available online 28 April 2016 Source:Molecular and Cellular Endocrinology Author(s): Vikas Sharma, Lokesh Kumar, Sujit K. Mohanty, Jagdamba P. Maikhuri, Singh Rajender, Gopal Gupta Epigenetic repression of Androgen Receptor (AR) gene by hypermethylation of its promoter causes resistance in prostate cancer (CaP) to androgen deprivation therapy with anti-androgens. Some dietary phytocompounds like quercetin (Q) and curcumin (C) with reported DNMT-inhibitory activity were tested for their ability to re-express the AR in AR-negative CaP cell lines PC3 and DU145. Combined treatment with Q+C was much m...
Source: Molecular and Cellular Endocrinology - April 28, 2016 Category: Endocrinology Source Type: research