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Source: Molecular Immunology

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Total 48 results found since Jan 2013.

Synergistic effect of pro-inflammatory TNFα and IL-17 in periostin mediated collagen deposition: Potential role in liver fibrosis
Conclusion TNFα and IL-17 induced fibrogenesis through cJun and STAT-3 mediated expression of profibrotic biomarker, periostin. Therefore, periostin might serve as a novel biomarker in early diagnosis of liver fibrosis.
Source: Molecular Immunology - November 11, 2014 Category: Allergy & Immunology Source Type: research

A novel post-transcriptional role for ubiquitin in the differential regulation of MHC class I allotypes
Publication date: September 2013 Source:Molecular Immunology, Volume 55, Issue 2 Author(s): Florencia Cano , Paul J. Lehner By providing ligands for Cytotoxic T-Lymphocytes (CTL) as well as Natural Killer (NK) cells, the HLA-A/B/C MHC class I molecules (MHC-I) play a central role in both innate and adaptive immunity. In addition to CTL-mediated recognition of MHC-peptide complexes, cell surface expression of MHC-I is closely monitored by NK cells, whose killer-cell immunoglobulin-like receptors encode activatory and inhibitory receptors with specificity for MHC-I. How the cell surface expression of MHC-I is tightly contr...
Source: Molecular Immunology - November 3, 2014 Category: Allergy & Immunology Source Type: research

Novel estrogen target gene ZAS3 is overexpressed in systemic lupus erythematosus
Publication date: May 2013 Source:Molecular Immunology, Volume 54, Issue 1 Author(s): Nicholas A. Young , Alexandra K. Friedman , Benjamin Kaffenberger , Murugesan V.S. Rajaram , Daniel J. Birmingham , Brad H. Rovin , Lee A. Hebert , Larry S. Schlesinger , Lai-Chu Wu , Wael N. Jarjour Systemic lupus erythematosus (SLE) is a prototypic, inflammatory autoimmune disease characterized by significant gender bias. Previous studies have established a role for hormones in SLE pathogenesis, including the sex hormone estrogen. Estrogen regulates gene expression by translocating estrogen receptors (ER) α and β into the nucleus wh...
Source: Molecular Immunology - November 3, 2014 Category: Allergy & Immunology Source Type: research