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Source: Molecular Immunology
Condition: Asthma
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Total 1 results found since Jan 2013.
Hypoxia-induced ADAM 17 expression is mediated by RSK1-dependent C/EBP β activation in human lung fibroblasts
In this study, we investigated the roles that ribosomal S-6 kinase 1 (RSK1)/CCAAT/enhancer-binding protein β (C/EBPβ)-dependent ADAM 17 expression plays in hypoxia-induced CTGF expression in human lung fibroblasts. We observed that hypoxia caused increases in ADAM 17 expression and ADAM 17-luciferase activity in WI-38 cells. Hypoxia-induced CTGF-luciferase activity and CTGF expression were reduced in cells transfected with small interfering (si)RNA of ADAM 17 in WI-38 cells. Moreover, hypoxia-induced ADAM 17 expression was reduced by RSK1 siRNA and C/EBPβ siRNA. Hypoxia caused time-dependent increases in RSK1 phosphoryl...
Source: Molecular Immunology - June 21, 2017 Category: Allergy & Immunology Source Type: research
