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TRPV6 channel modulates proliferation of insulin secreting INS-1E beta cell line
In conclusion, this study demonstrates for the first time the expression of TRPV6 in INS-1E cells and rat pancreatic beta cells and describes its role in modulating calcium signaling, beta cell proliferation and insulin mRNA expression. In contrast, TRPV6 fails to influence insulin secretion.
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - October 5, 2015 Category: Molecular Biology Source Type: research

CRNDE, a long non-coding RNA responsive to insulin/IGF signaling, regulates genes involved in central metabolism
Publication date: February 2014 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1843, Issue 2 Author(s): Blake C. Ellis , Lloyd D. Graham , Peter L. Molloy Colorectal neoplasia differentially expressed (CRNDE) is a novel gene that is activated early in colorectal cancer but whose regulation and functions are unknown. CRNDE transcripts are recognized as long non-coding RNAs (lncRNAs), which potentially interact with chromatin-modifying complexes to regulate gene expression via epigenetic changes. Complex alternative splicing results in numerous transcripts from this gene, and we have identifie...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - November 1, 2014 Category: Molecular Biology Source Type: research