• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Mutant p53 prevents GAPDH nuclear translocation in pancreatic cancer cells favoring glycolysis and 2-deoxyglucose sensitivity
Publication date: Available online 5 October 2018Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Giovanna Butera, Raffaella Pacchiana, Nidula Mullappilly, Marilena Margiotta, Stefano Bruno, Paola Conti, Chiara Riganti, Massimo DonadelliAbstractPancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and devastating human malignancies. In about 70% of PDACs the tumor suppressor gene TP53 is mutated generally resulting in conformational changes of mutant p53 (mutp53) proteins, which acquire oncogenic functions triggering aggressiveness of cancers and alteration of energetic metabo...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - October 6, 2018 Category: Molecular Biology Source Type: research

ZIP9 but not the androgen receptor mediates testosterone-induced migratory activity of metastatic prostate cancer cells
Publication date: Available online 15 September 2018Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Ahmed Bulldan, Joerg-Walter Bartsch, Lutz Konrad, Georgios Scheiner-BobisAbstractLNCaP cells are derived from a metastatic lesion of human prostate adenocarcinoma. They express the classical androgen receptor (AR) and ZIP9, a Zn2+ transporter that also binds testosterone and mediates signaling by interacting with G-proteins.Our results show that LNCaP cells respond to testosterone by mobilizing their migratory machinery. Their exposure to testosterone triggers the formation of lamellipodia, re...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - September 16, 2018 Category: Molecular Biology Source Type: research

Decrease in paracellular permeability and chemosensitivity to doxorubicin by claudin-1 in spheroid culture models of human lung adenocarcinoma A549 cells
Publication date: Available online 7 March 2018 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Risa Akizuki, Ryohei Maruhashi, Hiroaki Eguchi, Kazuki Kitabatake, Mitsutoshi Tsukimoto, Takumi Furuta, Toshiyuki Matsunaga, Satoshi Endo, Akira Ikari Chemotherapy resistance is a major problem in the treatment of cancer, but the underlying mechanisms are not fully understood. We found that the expression levels of claudin-1 (CLDN1) and 3, tight junctional proteins, are upregulated in cisplatin (CDDP)-resistant human lung adenocarcinoma A549 (A549R) cells. A549R cells showed cross-resistance to d...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - March 7, 2018 Category: Molecular Biology Source Type: research

Role of CCL20 mediated immune cell recruitment in NF- κB mediated TRAIL resistance of pancreatic cancer
In conclusion, our data show a functional role of a RelA-CCL20 pathway in PDAC TRAIL resistance. We demonstrate how the therapy-induced cross-talk of cancer cells with immune cells affects treatment responses, knowledge needed to tailor novel bi-specific treatments, which target tumor cell as well as immune cells. Graphical abstract
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - February 7, 2017 Category: Molecular Biology Source Type: research