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GSE98335 SZ 95 sebocytes - OLR1 knockdown - treated with UV-oxidized PAPC
Contributors : Ionela Nagelreiter ; Masomeh Parvadeh ; Marie Narzt ; Lucian Beer ; Christopher Kremslehner ; Ximena Muresan ; Johannes Grillari ; Christos Zouboulis ; Erwin Tschachler ; Florian GruberSeries Type : Expression profiling by arrayOrganism : Homo sapiensHuman SZ95 sebocytes were transfected by lipofection with either scramble siRNA or OLR1 siRNA and after 24h were treated with 25 µg/ml of UV-oxidized 1-palmitoyl-2-arachidonoyl-sn-phosphocholine (UVPAPC) for 7 hours. Phospholipid oxidation products (OxPL) are versatile stress signaling mediators in the skin. These lipid signaling molecules can be generated non-...
Source: GEO: Gene Expression Omnibus - April 15, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE145697 The role of lncRNA Sarrah in human cardiomyocytes
Contributors : Reinier A Boon ; D J TrembinskiSeries Type : Expression profiling by arrayOrganism : Homo sapiensLong non-coding RNAs (lncRNAs) contribute to (patho)physiological processes in the heart. Aging is the major risk factor for cardiovascular disease and cardiomyocyte apoptosis is an underlying cause for age-related cardiac dysfunction. RNA sequencing of cardiomyocytes from young and aged mouse hearts revealed several aging-regulated lncRNAs. An siRNA screen for caspase activity identified the aging-regulated lncRNA Sarrah (ENSMUST00000140003) as anti-apoptotic, which we confirmed in human cells (human SARRAH is a...
Source: GEO: Gene Expression Omnibus - February 22, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research