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GSE240039 Expression of PVRL4, a molecular target for cancer treatment, is transcriptionally regulated by FOS family protein ATAC
Contributors : Tomoyuki Nanamiya ; Kiyoko Takane ; Kiyoshi Yamaguchi ; Yoichi FurukawaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensNectin-4 or PVRL4 is a promising therapeutic target because its augmented expression has been found in a wide range of human cancers. It is of note that Enfortumab Vedotin, an ADC for PVRL4 is clinically used for the treatment of urothelial bladder cancer. In addition, rMV-SLAMblind, a genetically engineered oncolytic measles virus, can infect cancer cells and induce apoptosis through an interaction with PVRL4. Although the transcripts of ...
Source: GEO: Gene Expression Omnibus - August 10, 2023 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research

GSE236275 Expression of PVRL4, a molecular target for cancer treatment, is transcriptionally regulated by FOS family protein
Contributors : Tomoyuki Nanamiya ; Kiyoko Takane ; Kiyoshi Yamaguchi ; Yoichi FurukawaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNectin-4 or PVRL4 is a promising therapeutic target because its augmented expression has been found in a wide range of human cancers. It is of note that Enfortumab Vedotin, an ADC for PVRL4 is clinically used for the treatment of urothelial bladder cancer. In addition, rMV-SLAMblind, a genetically engineered oncolytic measles virus, can infect cancer cells and induce apoptosis through an interaction with PVRL4. Although the transcripts of PVRL4 are elev...
Source: GEO: Gene Expression Omnibus - July 31, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE146975 EGFR activity addiction facilitates anti-ERBB based combination treatment of squamous bladder cancer
Contributors : Michael Rose ; Bernd Denecke ; Nadine T GaisaSeries Type : Expression profiling by arrayOrganism :Recent findings suggested a benefit of anti-EGFR therapy for basal-like muscle invasive bladder cancer (MIBC). However, impact on bladder cancer with substantial squamous differentiated (Sq-BLCA) and especially pure squamous cell carcinoma (SCC) remains unknown. Therefore, we comprehensively characterized pure and mixed Sq-BLCA (n=125) on genetic and protein expression level, and performed functional pathway and drug-response analyses with cell line models and isolated primary SCC (p-SCC) cells of the human urin...
Source: GEO: Gene Expression Omnibus - March 12, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by array Source Type: research

GSE183793 Global gene expression of canine bladder K9TCC cells and cancer stem cells after COX-2 inhibition
Contributors : Emma A Hurst ; Lisa Y Pang ; David J ArgyleSeries Type : Expression profiling by arrayOrganism : Canis lupus ; Canis lupus familiarisCancer stem cells (CSCs) are fundamental to bladder cancer progression and the cyclooxygenase-2 (COX-2) pathway has a pro-tumorigenic role in CSC function. Naturally occurring bladder cancer in dogs has the potential to be a natural model of the human disease. Here, we used canine specific microarrays to determine changes in global gene expression of canine bladder cancer cells (the K9TCC cell line) and bladder cancer stem cells isolated from the K9TCC cell line after treatment...
Source: GEO: Gene Expression Omnibus - July 20, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Canis lupus Canis lupus familiaris Source Type: research

GSE139319 Differentially expressed genes after siRNA transfection in human cancer cell lines (SBC and T24)
Contributors : Naohiko Seki ; Yasutaka YamadaSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo identify differentially expressed genes by anti cancer treatments (miRNA) in human cancer, several cell lines (lung cancer and bladder cancer) were subjected to Agilent whole genome microarrays.
Source: GEO: Gene Expression Omnibus - October 25, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE115341 Expression data from bladder cancer cells T24 - treated with G9a siRNA or negative control siRNA
Contributors : Jun Yan ; Jingya SunSeries Type : Expression profiling by arrayOrganism : Homo sapiensTarget genes regulated by G9a in bladder cancer cells T24In this dataset, we include the expression data obtained from bladder cancer cells T24 treated with G9a siRNA or negative control siRNA. These data are used to obtain genes that are differentially expressed in response to G9a konckdown.
Source: GEO: Gene Expression Omnibus - May 29, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE117193 The induction of core pluripotency master regulators in cancers defines poor clinical outcomes and treatment resistance
Contributors : Anastasia Hepburn ; Rebecca E Steele ; Rajan Veeratterapillay ; Laura Wilson ; Amy Barnard ; Philip Berry ; James Cassidy ; Mohammad Moad ; Amira El-Sherif ; Luke Gaughan ; Ian G Mills ; Craig Robson ; Rakesh HeerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensClinical expression of core pluripotent stem cell master regulators OCT4, SOX2 and NANOG is associated with treatment resistance and lethal cancers. We have described a novel model to induce the expression of these factors in vitro. We term this culture environment ‘Acquired Pluripotent Stem Cell Environment (AP...
Source: GEO: Gene Expression Omnibus - February 25, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE115801 Differentially expressed genes after miRNA or siRNA transfection in human cancer cell lines III
Contributors : Naohiko Seki ; Takayuki AraiSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo identify differentially expressed genes by anti cancer treatments (microRNAs or siRNAs) in human cancer, several cell lines ( pancreatic cancer, renal cell carcinoma, oral squamous cell carcinoma, prostate cancer and bladder cancer) were subjected to Agilent whole genome microarrays.
Source: GEO: Gene Expression Omnibus - June 15, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE106791 Differentially expressed genes after miRNA or siRNA transfection in multiple human cancer cell lines
Contributors : Naohiko Seki ; Takayuki AraiSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo identify differentially expressed genes by anti cancer treatments (microRNAs or siRNAs) in human cancer, several cell lines ( pancreatic cancer, renal cell carcinoma, oral squamous cell carcinoma, prostate cancer and bladder cancer) were subjected to Agilent whole genome microarrays.
Source: GEO: Gene Expression Omnibus - November 14, 2017 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE81629 Gene expression profile changes after ANLN knockdown in J82 cells
Contributors : Chuanliang Xu ; Shuxiong ZengSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo investigate gene expression profile changes after ANLN knockdown, we have employed whole genome microarray expression profiling as a discovery platform to identify genes that altered after ANLN knockdown, so as to explore the potential function of ANLN. Bladder cancer cell line J82 was knocked down by using small interfering RNA (siRNA) or control siRNA 24, 48 and 72 hours, respectively.
Source: GEO: Gene Expression Omnibus - February 24, 2017 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE77883 Enzalutamide inhibits proliferation of gemcitabine-resistant bladder cancer cells with increased androgen receptor expression
Contributors : Toshio Kojima ; Koji Kameyama ; Taku Kato ; Yasunori Fujita ; Kyojiro Kawakami ; Kosuke Mizutani ; Takashi Deguchi ; Masafumi ItoSeries Type : Expression profiling by arrayOrganism : Homo sapiensAdvanced bladder cancer is treated mainly with gemcitabine and cisplatin, but most patients eventually become resistance to these chemotherapeutic agents. Androgen receptor (AR) signaling has been implicated in bladder cancer as well as other types of cancer including prostate cancer. In the present study, we showed the expression and role of AR in gemcitabine-resistant bladder cancer cells and examined the potential...
Source: GEO: Gene Expression Omnibus - November 30, 2016 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE77790 Differentially expressed genes after miRNA or siRNA transfection in human cancer cell lines II
Contributors : Naohiko Seki ; Yusuke GotoSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo identify differentially expressed genes by anti cancer treatments (microRNAs or siRNAs) in human cancer, several cell lines (pancreatic cancer, esophageal cancer, bladder cancer, prostate cancer, renal cell carcinoma and lung squamous cell carcinoma) were subjected to Agilent whole genome microarrays.
Source: GEO: Gene Expression Omnibus - April 13, 2016 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE66498 Differentially expressed genes after miRNA or siRNA transfection in human cancer cell lines (II)
Contributor : Naohiko SekiSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo identify differentially expressed genes by anti cancer treatments (microRNAs or siRNAs) in human cancer, several cell lines (bladder cancer, prostate cancer, renal cell carcinoma, oral squamous cell carcinoma and lung squamous cell carcinoma) were subjected to Agilent whole genome microarrays.
Source: GEO: Gene Expression Omnibus - April 13, 2016 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE56243 Differentially expressed genes after miRNA or siRNA transfection in human cancer cell lines
Contributor : Naohiko SekiSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo identify differentially expressed genes by anti cancer treatments (microRNAs or siRNAs) in human cancer, several cell lines (bladder cancer, prostate cancer, hypopharyngeal cancer and lung squamous cell carcinoma) were subjected to Agilent whole genome microarrays.
Source: GEO: Gene Expression Omnibus - April 13, 2016 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research