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A multimolecular signaling complex including PrPC and LRP1 is strictly dependent on lipid rafts and is essential for the function of tissue Plasminogen Activator
AbstractPrion protein (PrPC) localizes stably in lipid rafts microdomains and is able to recruit downstream signal transduction pathways by the interaction with promiscuous partners. Other proteins have the ability to occasionally be recruited to these specialized membrane areas, within multimolecular complexes. Among these, we highlight the presence of the low ‐density lipoprotein receptor related protein 1 (LRP1), which was found localize transiently in lipid rafts, suggesting a different function of this receptor that through lipid raft becomes able to activate a signal transduction pathway triggered by specific ligan...
Source: Journal of Neurochemistry - October 10, 2019 Category: Neuroscience Authors: Vincenzo Mattei, Valeria Manganelli, Stefano Martellucci, Antonella Capozzi, Elisabetta Mantuano, Agostina Longo, Alberto Ferri, Tina Garofalo, Maurizio Sorice, Roberta Misasi Tags: ORIGINAL ARTICLE Source Type: research

Calcipotriol inhibits α‐synuclein aggregation in SH‐SY5Y neuroblastoma cells by a Calbindin‐D28K‐dependent mechanism
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - February 5, 2017 Category: Neuroscience Authors: Alexandre N. Rcom ‐H'cheo‐Gauthier, Adrian C. B. Meedeniya, Dean L. Pountney Tags: Original Article Source Type: research

Cholesterol‐rich lipid rafts are involved in neuropeptide FF anti‐nociceptin/orphanin FQ effect
Abstract The participation of a signaling platform to the anti‐nociceptin/orphanin FQ (N/OFQ) effect of neuropeptide FF (NPFF) receptors was investigated in both acutely dissociated neurons and SH‐SY5Y human neuroblastoma cells. The NPFF anti‐N/OFQ, not anti‐μ opioid effect, on the Ca2+ transient triggered by depolarization was reversed by methyl‐β‐cyclodextrin which depletes cholesterol from cell membranes. While the inactive α‐cyclodextrin had no effect. By using [35S]GTPγS binding assay, a significant 20% decrease in the activity of nociceptin/orphanin FQ peptide receptors induced by the NPFF analog 1D...
Source: Journal of Neurochemistry - December 27, 2015 Category: Neuroscience Authors: Zhong Ding, Jean‐Marie Zajac Tags: Original Article Source Type: research

Cholesterol‐rich lipid rafts are involved in Neuropeptide FF anti‐Nociceptin/Orphanin FQ effect
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - November 30, 2015 Category: Neuroscience Authors: Zhong Ding, Jean‐Marie Zajac Tags: Original Article Source Type: research