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Mnk1 (Mitogen-Activated Protein Kinase-Interacting Kinase 1) Deficiency Aggravates Cardiac Remodeling in MiceNovelty and Significance Heart
Identifying the key factor involved in cardiac remodeling is critically important for developing novel strategies to protect against heart failure. Here, the role of Mnk1 (mitogen-activated protein kinase–interacting kinase 1) in cardiac remodeling was clarified. Cardiac remodeling was induced by transverse aortic constriction in Mnk1-knockout mice and their wild-type control mice. After 4 weeks of transverse aortic constriction, Mnk1-knockout mice developed exaggerated cardiac hypertrophy, fibrosis, dysfunction, and cardiomyocyte apoptosis and showed increased ERK1/2 (extracellular signal–regulated kinase 1/2) activat...
Source: Hypertension - November 8, 2016 Category: Cardiology Authors: Yuan, Y., Yan, L., Wu, Q.-Q., Zhou, H., Jin, Y.-G., Bian, Z.-Y., Deng, W., Yang, Z., Shen, D.-F., Zeng, X.-F., Wang, S.-S., Li, H., Tang, Q.-Z. Tags: Hypertrophy, Remodeling Original Articles Source Type: research

Abstract 47: Caveolin-1 is Critical for Abdominal Aortic Aneurysm Induced by Angiotensin II Oral Session VI: Concurrent B Vascular Remodeling and Dysfunction
In conclusion, Cav1 and presumably vascular caveolae microdomains appear to play a critical role in the formation of AAA by Ang II via regulation of the ADAM17/EGFR signaling and subsequent ER/oxidative stress.
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Obama, T., Takayanagi, T., Crawford, K. J., Kobayashi, T., Rizzo, V., Eguchi, S. Tags: Oral Session VI: Concurrent B Vascular Remodeling and Dysfunction Source Type: research

Estrogen Receptor-{beta} in the Paraventricular Nucleus and Rostroventrolateral Medulla Plays an Essential Protective Role in Aldosterone/Salt-Induced Hypertension in Female Rats Estrogen
The identification of the specific estrogen receptor (ER) subtypes that are involved in estrogen protection from hypertension and their specific locations in the central nervous system is critical to our understanding and design of effective estrogen replacement therapies in women. Using selective ER agonists and recombinant adeno-associated virus (AAV) carrying small interference (si) RNA to silence either ERα (AAV-siRNA-ERα) or ERβ (AAV-siRNA-ERβ), the present study investigated regional specificity of different ER subtypes in the protective actions of estrogen in aldosterone (Aldo)-induced hyperten...
Source: Hypertension - May 15, 2013 Category: Cardiology Authors: Xue, B., Zhang, Z., Beltz, T. G., Johnson, R. F., Guo, F., Hay, M., Johnson, A. K. Tags: Animal models of human disease, Other hypertension Estrogen Source Type: research