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Abstract 146: MicroRNA-216a Promotes M1 Macrophages Polarization Through the Activation of Telomerase Session Title: Developmental Programming and Pregnancy Induced Hypertension
Conclusions: Our data indicated that miR-216a promotes M1 macrophages polarization through the activation of telomerase and reduces collagen III in mice carotid lesions, and ultimately accelerates the development of atherosclerosis.
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Shujun Yang, Jian Li, Yu Chen, Rutai Hui, Weili Zhang Tags: Oral Abstract Presentations Source Type: research

Abstract 036: Regulation of sFlt-1 Splicing by U2AF and JMJD Session Title: Pregnancy and Preeclampsia
Preeclampsia (PE) is a gestational disorder defined by new-onset hypertension and maternal endothelial dysfunction. Though its origins are unclear, placental ischemia is thought to be the central cause. In response, the placenta releases pathogenic factors, such as the anti-angiogenic soluble form of the VEGF receptor Flt-1 (sFlt-1), into the maternal circulation. sFlt-1 is a soluble splice variant of the VEGF receptor Flt-1, acting as a VEGF sink in the circulation. The regulation of sFlt-1 splicing is not completely understood, but it is proposed that the splicing factor U2AF65 promotes splicing, while JMJD6 opposes it b...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Adrian C Eddy, Heather Chapman, Eric M George Tags: Oral Abstract Presentations Source Type: research

Abstract P310: Atuplex Formulated With Small Interfering RNA For Soluble Fms-like Tyrosine Kinase-1 (sFLT1) Selectively Silences Maternal And Placental sFLT1 In A Preeclamptic Rat Model Session Title: Pregnancy and Preeclampsia and Developmental Programming of Cardiovascular Disease
Preeclampsia is a pregnancy-related disorder characterized by hypertension and proteinuria, affecting about 5-8% of pregnancies. It is a major cause of fetal and maternal morbidity/mortality. The disease is most probably multifactorial and caused by several placental dysfunctions. As an important mediator, sFLT1 is induced in the placenta and in the serum of preeclamptic women, acting as a decoy receptor for placenta like growth factors (PLGF) and inducing an antiangiogenic balance. RNAi mediated gene specific silencing could represent a new therapeutic option in preeclampsia management. We tested sFLT1-specific small inte...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Nadine Haase, Kristin Kraker, Ute Schaeper, Jens Endruschat, Dominik N Muller, Ralf Dechend Tags: Poster Abstract Presentations Source Type: research

Hypoxia-Independent Upregulation of Placental Hypoxia Inducible Factor-1{alpha} Gene Expression Contributes to the Pathogenesis of Preeclampsia Preeclampsia
Accumulation of hypoxia inducible factor-1α (HIF-1α) is commonly an acute and beneficial response to hypoxia, whereas chronically elevated HIF-1α is associated with multiple disease conditions, including preeclampsia, a serious hypertensive disease of pregnancy. However, the molecular basis underlying the persistent elevation of placental HIF-1α in preeclampsia and its role in the pathogenesis of preeclampsia are poorly understood. Here we report that Hif-1α mRNA and HIF-1α protein were elevated in the placentas of pregnant mice infused with angiotensin II type I receptor agonistic autoa...
Source: Hypertension - May 13, 2015 Category: Cardiology Authors: Iriyama, T., Wang, W., Parchim, N. F., Song, A., Blackwell, S. C., Sibai, B. M., Kellems, R. E., Xia, Y. Tags: Other hypertension Preeclampsia Source Type: research

Abstract 275: Tissue Transglutaminase Stabilizes Placental AT1 Receptor and Contributes to Pathophysiology in Preeclampsia Poster Session I
Preeclampsia (PE) is a serious hypertensive disease of pregnancy associated with the presence of the major angiotensin receptor AT1-agnostic autoantibodies (AT1-AAs) that cause the defining PE features when introduced into pregnant mice. To understand AT1-AA-mediated receptor activation in PE, we explored the role of tissue transglutaminases (TG2), the most ubiquitous member of a group of enzymes modifying proteins by catalyzing the formation of -(-glutamyl)-lysine isopeptide bonds. TG2, a versatile protein that can also function as a G protein, is enriched in the syncytiotrophoblasts of placenta, the key organ in PE patho...
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Liu, C., Wang, W., Parchim, N., Irani, R., Ning, C., Sun, K., Zhao, S., Zhao, C., Song, A., Zhang, Y., Blackwell, S., Sibai, B., Jin, J., Kellems, R., Xia, Y. Tags: Poster Session I Source Type: research

Abstract 277: Elevated C-Reactive Protein Contributes to Preeclampsia via Kinin Signaling Pathways Poster Session I
Preeclampsia (PE) is a serious pregnancy disease characterized by hypertension and proteinuria. Despite intensive research efforts, the underlying cause of PE remains a mystery. PE is, however, associated with abnormalities of the immune system. Here we report that the levels of C-reactive protein (CRP), an important acute phase reactant, were significantly elevated in the plasma of human with PE at the third trimester. Next, we found that CRP protein levels in the placentas of PE patients were also significantly increased compared to controls. In an effort to determine the exact role of elevated CRP in PE, we infused CRP ...
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Parchim, N., Wang, W., Iriyama, T., Liu, C., Siddiqui, A. H., Blackwell, S., Sibai, B., Kellems, R. E., Xia, Y. Tags: Poster Session I Source Type: research

Abstract 280: Sflt-1 is Regulated via Both Transcriptional and Post-transcriptional Modification in Preeclampsia Poster Session I
Preeclampsia (PE) is a life-threatening hypertensive renal disorder of pregnancy. Soluble fms-like tyrosine kinase 1 (sFlt-1), an anti-angiogenic factor, is elevated and contributes to PE. However, molecular basis underlying its up-regulation in PE remains unclear. Here we report that hypoxia inducible factor-1α (HIF-1α), an important transcriptional factor, and U2AF65, a key molecule involved in alternative splicing, are significantly increased in the placentasof PE patients compared to the controls. Using two animal models of PE including angiotensin receptor type 1 receptor agonistic autoantibody (AT1-AA) an...
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Wang, W., Parchim, N., Iriyama, T., Luo, R., Zhao, C., Zhang, Y., Blackwell, S., Sabai, B., Tao, L., Kellems, R., Xia, Y. Tags: Poster Session I Source Type: research