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Source: Hypertension
Condition: Pulmonary Hypertension
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STIM2 (Stromal Interaction Molecule 2)-Mediated Increase in Resting Cytosolic Free Ca2+ Concentration Stimulates PASMC Proliferation in Pulmonary Arterial HypertensionNovelty and Significance Pulmonary Hypertension
An increase in cytosolic free Ca2+ concentration ([Ca2+]cyt) in pulmonary artery smooth muscle cells (PASMCs) triggers pulmonary vasoconstriction and stimulates PASMC proliferation leading to vascular wall thickening. Here, we report that STIM2 (stromal interaction molecule 2), a Ca2+ sensor in the sarcoplasmic reticulum membrane, is required for raising the resting [Ca2+]cyt in PASMCs from patients with pulmonary arterial hypertension (PAH) and activating signaling cascades that stimulate PASMC proliferation and inhibit PASMC apoptosis. Downregulation of STIM2 in PAH-PASMCs reduces the resting [Ca2+]cyt, whereas overexpre...
Source: Hypertension - February 7, 2018 Category: Cardiology Authors: Shanshan Song, Shane G. Carr, Kimberly M. McDermott, Marisela Rodriguez, Aleksandra Babicheva, Angela Balistrieri, Ramon J. Ayon, Jian Wang, Ayako Makino, Jason X.-J. Yuan Tags: Pulmonary Hypertension, Vascular Disease Original Articles Source Type: research
