• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Placental growth factor silencing ameliorates liver fibrosis and angiogenesis and inhibits activation of hepatic stellate cells in a murine model of chronic liver disease
This study aimed to assess the effect of reducing PlGF expression using small interfering RNA (siRNA) on experimental liver fibrosis and angiogenesis, and to elucidate the underlying molecular mechanisms. Fibrosis was induced in mice by carbon tetrachloride (CCl4) for 8 weeks, and mice were treated with PlGF siRNA or non‐targeting control siRNA starting two weeks after initiating CCl4 injections. The results showed that PlGF was highly expressed in cirrhotic human and mice livers; which mainly distributed in activated hepatic stellate cells (HSCs). PlGF silencing robustly reduced liver inflammation, fibrosis, intrahepati...
Source: Journal of Cellular and Molecular Medicine - April 1, 2017 Category: Molecular Biology Authors: Xi Li, Qun ‐Yan Yao, Hong‐Chun Liu, Qian‐Wen Jin, Bei‐Li Xu, Shun‐Cai Zhang, Chuan‐Tao Tu Tags: Original Article Source Type: research

ASPP2 attenuates triglycerides to protect against hepatocyte injury by reducing autophagy in a cell and mouse model of non‐alcoholic fatty liver disease
In conclusion, ASPP2 may participate in the lipid metabolism of non‐alcoholic steatohepatitis and attenuate liver failure.
Source: Journal of Cellular and Molecular Medicine - September 25, 2014 Category: Molecular Biology Authors: Fang Xie, Lin Jia, Minghua Lin, Ying Shi, Jiming Yin, Yin Liu, Dexi Chen, Qinghua Meng Tags: Original Article Source Type: research