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Source: Phytomedicine
Condition: Chronic Kidney Disease
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Total 1 results found since Jan 2013.
Novel RAS inhibitor 25-O-methylalisol F attenuates epithelial-to-mesenchymal transition and tubulo-interstitial fibrosis by selectively inhibiting TGF- β-mediated Smad3 phosphorylation
Conclusions MAF simultaneously targeted multiple RAS components and it was a novel RAS inhibitor. MAF inhibited EMT by Smad3-specific signaling in the TGF-β/Smad-dependent pathway and Wnt1/β-catenin pathway. MAF has an important effect on crosstalk between the TGF-β/Smad and Wnt/β-catenin pathway in EMT process by activation of RAS. Graphical abstract
Source: Phytomedicine - March 20, 2018 Category: Drugs & Pharmacology Source Type: research
