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A novel hybrid of 3-benzyl coumarin seco-B-ring derivative and phenylsulfonylfuroxan induces apoptosis and autophagy in non-small-cell lung cancer
ConclusionThese findings raise a rationale that this 3-benzyl coumarin seco-B-ring derivative and phenylsulfonylfuroxan hybrid could be a promising candidate for developing as a therapeutic agent toward NSCLC, and the combination therapy through PI3K/Akt/mTOR signaling pathway may result in optimized treatment outcomes.Graphical Abstract
Source: Phytomedicine - October 5, 2018 Category: Drugs & Pharmacology Source Type: research

Identification of Amentoflavone as a potent highly selective PARP-1 inhibitor and its potentiation on carboplatin in human Non-Small Cell Lung Cancer
ConclusionsAll results suggest that AMF can be a potential PARP-1 inhibitor and a candidate adjuvant agent to boost the anticancer effect of CBP in NSCLC.Graphical abstract
Source: Phytomedicine - September 6, 2018 Category: Drugs & Pharmacology Source Type: research

Dendrobine targeting JNK stress signaling to sensitize chemotoxicity of cisplatin against non-small cell lung cancer cells in vitro and in vivo
ConclusionsThe combination treatment showed enhanced anticancer activity toward non-small cell lung cancer cells without aggravating the cardiotoxic effects of cisplatin suggesting that the combination strategy deserves further investigation for human lung cancer treatment.Graphical Abstract
Source: Phytomedicine - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Dendrobine targeting JNK stress signaling to sensitize chemotoxicity of cisplatin against non-small cell  lung cancer cells in vitro and in vivo
Conclusions The combination treatment showed enhanced anticancer activity toward non-small cell lung cancer cells without aggravating the cardiotoxic effects of cisplatin suggesting that the combination strategy deserves further investigation for human lung cancer treatment. Graphical abstract
Source: Phytomedicine - June 28, 2018 Category: Drugs & Pharmacology Source Type: research

A hybrid of coumarin and phenylsulfonylfuroxan induces caspase-dependent apoptosis and cytoprotective autophagy in lung adenocarcinoma cells
Conclusion : This results demonstrate that compound 8b induces caspase-dependent apoptosis as well as cytoprotective autophagy in lung adenocarcinoma cells, which may provide scientific evidence for developing this furoxan-based NO-releasing coumarin derivative as a potential anti-lung adenocarcinoma therapeutic agents. Graphical abstract
Source: Phytomedicine - December 26, 2017 Category: Drugs & Pharmacology Source Type: research

Mistletoe (viscum album) extract targets Axl to suppress cell proliferation and overcome cisplatin- and erlotinib-resistance in non-small cell lung cancer cells.
Conclusion : Taken together, our data provide that VAE targets Axl to suppress cell proliferation and to circumvent cisplatin- and erlotinib-resistance in NSCLC cells. Graphical abstract
Source: Phytomedicine - September 29, 2017 Category: Drugs & Pharmacology Source Type: research