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TGFβ‐Responsive HMOX1 Expression Is Associated with Stemness and Invasion in Glioblastoma Multiforme
Abstract Glioblastoma multiforme (GBM) is the most common and lethal adult brain tumor. Resistance to standard radiation and chemotherapy is thought to involve survival of GBM cancer stem cells (CSCs). To date, no single marker for identifying GBM CSCs has been able to capture the diversity of CSC populations, justifying the needs for additional CSC markers for better characterization. Employing targeted mass spectrometry, here we present five cell‐surface markers HMOX1, SLC16A1, CADM1, SCAMP3, and CLCC1 which were found to be elevated in CSCs relative to healthy neural stem cells (NSCs). Transcriptomic analyses of REMBR...
Source: Stem Cells - July 3, 2016 Category: Stem Cells Authors: Dhiman Ghosh, Ilya V. Ulasov, LiPing Chen, Lualhati E. Harkins, Karolina Wallenborg, Parvinder Hothi, Steven Rostad, Leroy Hood, Charles S. Cobbs Tags: Cancer Stem Cell Source Type: research

TGF β‐Responsive HMOX1 Expression Is Associated with Stemness and Invasion in Glioblastoma Multiforme
Abstract Glioblastoma multiforme (GBM) is the most common and lethal adult brain tumor. Resistance to standard radiation and chemotherapy is thought to involve survival of GBM cancer stem cells (CSCs). To date, no single marker for identifying GBM CSCs has been able to capture the diversity of CSC populations, justifying the needs for additional CSC markers for better characterization. Employing targeted mass spectrometry, here we present five cell‐surface markers HMOX1, SLC16A1, CADM1, SCAMP3, and CLCC1 which were found to be elevated in CSCs relative to healthy neural stem cells (NSCs). Transcriptomic analyses of REMBR...
Source: Stem Cells - July 3, 2016 Category: Stem Cells Authors: Dhiman Ghosh, Ilya V. Ulasov, LiPing Chen, Lualhati E. Harkins, Karolina Wallenborg, Parvinder Hothi, Steven Rostad, Leroy Hood, Charles S. Cobbs Tags: Cancer Stem Cell Source Type: research

TGFβ‐Responsive HMOX1 Expression is Associated with Stemness and Invasion in GBM
This article is protected by copyright. All rights reserved. Targeted proteomic analyses revealed elevated expressions of transmembrane proteins HMOX1 and SLC16A1 on the surface of glioblastoma cancer stem cells (CSCs) relative to healthy neural stem cells (NSCs). In the hypoxic region of the tumor, these proteins were found to be expressed among pseudopalisading glioma cells that also express known stem cell factors. From biological assays that are known to evaluate stemness, HMOX1 expression was found to be associated with stemness that could be regulated through TGFβ and PTEN signaling networks. Additionally, siRNA me...
Source: Stem Cells - June 28, 2016 Category: Stem Cells Authors: Dhiman Ghosh, Ilya V. Ulasov, LiPing Chen, Karolina Wallenborg, Parvinder Hothi, Leroy Hood, Charles S. Cobbs Tags: Cancer Stem Cells Source Type: research