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The PI3K/AKT/c ‐MYC Axis Promotes the Acquisition of Cancer Stem‐Like Features in Esophageal Squamous Cell Carcinoma
In conclusion, we have described a novel intratumoral heterogeneity in ESCC. The identification of the PI3K/AKT/c‐MYC axis as a driver of CSC‐like features carries therapeutic implications. Stem Cells 2016;34:2040–2051 Oxidative stress induced by H2O2 promotes RU/RR conversion and the acquisition of CSC‐like properties. (A) Reactive oxygen species (ROS) induced by H2O2 (500 μM for 24 hours) was measured by flow cytometry. (B) H2O2‐induced RU/RR conversion in KYSE150‐RU cells, as indicated by the increase of GFP‐positive cells and luciferase activity. Representative flow cytometry data at Day 4 was shown in...
Source: Stem Cells - May 22, 2016 Category: Stem Cells Authors: Hai ‐Feng Zhang, Chengsheng Wu, Abdulraheem Alshareef, Nidhi Gupta, Qing Zhao, Xiu‐E Xu, Ji‐Wei Jiao, En‐Min Li, Li‐Yan Xu, Raymond Lai Tags: Cancer Stem Cells Source Type: research

The PI3K/AKT/c‐MYC axis promotes the acquisition of cancer stem‐like features in esophageal squamous cell carcinoma
In conclusion, we have described a novel intra‐tumoral heterogeneity in ESCC. The identification of the PI3K/AKT/c‐MYC axis as a driver of CSC‐like features carries therapeutic implications. This article is protected by copyright. All rights reserved. Oxidative stress induced by H2O2 promotes RU/RR conversion and the acquisition of CSC‐like properties. (A) Reactive oxygen species (ROS) induced by H2O2 (500μM for 24h) was measured by flow cytometry. (B) H2O2‐induced RU/RR conversion in KYSE150‐RU cells, as indicated by the increase of GFP‐positive cells and luciferase activity. Representative flow cytometry ...
Source: Stem Cells - March 31, 2016 Category: Stem Cells Authors: Hai‐Feng Zhang, Chengsheng Wu, Abdulraheem Alshareef, Nidhi Gupta, Qing Zhao, Xiu‐E Xu, Ji‐Wei Jiao, En‐Min Li, Li‐Yan Xu, Raymond Lai Tags: Cancer Stem Cells Source Type: research

Peroxiredoxin II is essential for maintaining stemness by redox regulation in liver cancer cells
This article is protected by copyright. All rights reserved.
Source: Stem Cells - February 11, 2016 Category: Stem Cells Authors: Taeho Kwon, Yesol Bak, Young‐Ho Park, Gyu‐Beom Jang, Jeong‐Seok Nam, Jeong Eun Yoo, Young Nyun Park, In Seon Bak, Jin‐Man Kim, Do‐Young Yoon, Dae‐Yeul Yu Tags: Cancer Stem Cells Source Type: research

Focal Adhesion Kinase and Wnt Signaling Regulate Human Ductal Carcinoma In Situ Stem Cell Activity and Response to Radiotherapy
Abstract Cancer stem cells (CSCs) can avoid or efficiently repair DNA damage from radio and chemotherapy, which suggests they play a role in disease recurrence. Twenty percentage of patients treated with surgery and radiotherapy for ductal carcinoma in situ (DCIS) of the breast recur and our previous data show that high grade DCIS have increased numbers of CSCs. Here, we investigate the role of focal adhesion kinase (FAK) and Wnt pathways in DCIS stem cells and their capacity to survive irradiation. Using DCIS cell lines and patient samples, we demonstrate that CSC‐enriched populations are relatively radioresistant and p...
Source: Stem Cells - January 22, 2015 Category: Stem Cells Authors: Kathryn E. Williams, Nigel J. Bundred, Göran Landberg, Robert B. Clarke, Gillian Farnie Tags: Cancer Stem Cells Source Type: research

Focal adhesion kinase and wnt signalling regulates human ductal carcinoma in situ stem cell activity and response to radiotherapy
Abstract Cancer stem cells (CSCs) can avoid or efficiently repair DNA damage from radio and chemotherapy, which suggests they play a role in disease recurrence. 20% of patients treated with surgery and radiotherapy for ductal carcinoma in Situ (DCIS) of the breast recur and our previous data shows that high grade DCIS have increased numbers of CSCs. Here, we investigate the role of Focal Adhesion Kinase (FAK) and Wnt pathways in DCIS stem cells and their capacity to survive irradiation. Using DCIS cell lines and patient samples we demonstrate that CSC‐enriched populations are relatively radioresistant and possess high FA...
Source: Stem Cells - September 3, 2014 Category: Stem Cells Authors: Kathryn E Williams, Nigel J Bundred, Göran Landberg, Robert B Clarke, Gillian Farnie Tags: Original Research Source Type: research